YTHDC2 - YTH domain containing 2 Gene

Also Known as CAHL; hYTHDC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64848

About YTHDC2

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:113,513,694-113,595,284 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 9.0), lymph node (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic Cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver Cancer cell line. [provided by RefSeq, Sep 2016]

YTHDC2 Products (3)

mRNA Protein Name
NM_001345975.2 NP_001332904.1 3'-5' RNA helicase YTHDC2 isoform 2
NM_001345976.2 NP_001332905.1 3'-5' RNA helicase YTHDC2 isoform 3
NM_022828.5 NP_073739.3 3'-5' RNA helicase YTHDC2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' RNA helicase activity IDA
IDA: Inferred from direct assay
29033321 GOA
enables ATP-dependent activity, acting on RNA IDA
IDA: Inferred from direct assay
21559518 GOA
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
26318451 GOA
enables RNA polymerase binding IPI
IPI: Inferred from physical interaction
21559518 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation by host of viral genome replication IMP
IMP: Inferred from mutant phenotype
21559518 GOA
involved in response to interleukin-1 IDA
IDA: Inferred from direct assay
21559518 GOA
involved in response to tumor necrosis factor IDA
IDA: Inferred from direct assay
21559518 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21559518 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDC2 Protein Structure

R3H

R3H: R3H domain (42 - 105)

DEAD

DEAD: DEAD/DEAH box helicase (198 - 352)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (487 - 565)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (655 - 743)

HA2

HA2: Helicase associated domain (HA2) (808 - 901)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (939 - 1065)

YTH

YTH: YT521-B-like domain (1288 - 1420)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1430 a.a.
Protein Preferred Names Protein Names

3'-5' RNA helicase YTHDC2

  • CsA-associated helicase-like protein

YTHDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
YTHDC2 Q9H6S0 Meioc Mus musculus A2AG06
Anti Tag CoIP
26742488
Intra
YTHDC2 Q9H6S0 IRF4 Homo sapiens Q15306
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168610 YTH-IN-1 Inhibitor 98.66% Unkown
HY-181117 YTH-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YTHDC2 MGD MGI:2448561
Canis familiaris YTHDC2 VGNC VGNC:48504
Rattus norvegicus YTHDC2 RGD RGD:1563192
Bos taurus YTHDC2 VGNC VGNC:37040
Macaca mulatta YTHDC2 VGNC VGNC:79452
Others YTHDC2 NCBI