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Cat. No.: HY-P86042

MUM1 Antibody (YA5734)

Name: MUM1 Antibody (YA5734)
Brand: MedChemExpress
SKU: HY-P86042
Availability: PreOrder

(Synonyms: Interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5; )

MUM1 Antibody (YA5734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:200-400	1:500-5000

Description

MUM1 Antibody (YA5734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 52 kDa

Immunogen

Synthesized peptide derived from human MUM1 AA range: 350-451

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

MUM1 transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes
Subcellular Localization

Nucleus; Cytoplasm
Expression

Tissue_specificity:lymphocytes

Induction:Not induced by interferons
Isoforms & Post-Translational Modification

Q15306 has 2 isomers: Q15306-1: 51772 Da (predicted); Q15306-2: 51644 Da (predicted).
Phosphorylation by ROCK2 regulates IL-17 and IL-21 production
Subunit

Interacts with SPIB (PubMed:10196196). Interacts with DEF6 (PubMed:12651066). Interacts with SPI1 (PubMed:33951726)
SwissProt ID

Q15306
Gene ID

3662 [NCBI]
Synonyms

Interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5;