GIPC2 - GIPC PDZ domain containing family member 2 Gene

Also Known as SEMCAP2; SEMCAP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54810

About GIPC2

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:78,044,970-78,138,444 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues and 2 paralogues. Broad expression in kidney (RPKM 20.2), small intestine (RPKM 19.8) and 18 other tissues.

Summary

Enables identical protein binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GIPC2 Products (2)

mRNA Protein Name
NM_001304725.2 NP_001291654.1 PDZ domain-containing protein GIPC2 isoform 2
NM_017655.6 NP_060125.4 PDZ domain-containing protein GIPC2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIPC2 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (118 - 189)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

PDZ domain-containing protein GIPC2

  • PDZ domain protein GIPC2

GIPC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GIPC2 Q8TF65 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
GIPC2 Q8TF65 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 CTRC Homo sapiens Q99895
Validated Y2H
32296183
Intra
GIPC2 Q8TF65 INADL Homo sapiens A5PKX9
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 INADL Homo sapiens A5PKX9
Y2H Array
32296183
Intra
GIPC2 Q8TF65 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
25416956
Intra
GIPC2 Q8TF65 PLEKHA2 Homo sapiens Q9HB19
Validated Y2H
32296183
Intra
GIPC2 Q8TF65 PLEKHA2 Homo sapiens Q9HB19
Y2H Array
32296183
Intra
GIPC2 Q8TF65 PLEKHA2 Homo sapiens Q9HB19
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 SP100 Homo sapiens P23497-2
Y2H Array
32296183
Intra
GIPC2 Q8TF65 SP100 Homo sapiens P23497-2
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 GIPC2 Homo sapiens Q8TF65
Validated Y2H
32296183
Intra
GIPC2 Q8TF65 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 GIPC2 Homo sapiens Q8TF65
Y2H Array
32296183
Intra
GIPC2 Q8TF65 GIPC2 Homo sapiens Q8TF65
Y2H Array
25416956
Intra
GIPC2 Q8TF65 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
GIPC2 Q8TF65 GIPC2 Homo sapiens Q8TF65
Complementation
32296183
Intra
GIPC2 Q8TF65 SP100 Homo sapiens P23497
Y2H Array
31515488
Intra
GIPC2 Q8TF65 SP100 Homo sapiens P23497
Y2H Prey Pooling
25416956
Intra
GIPC2 Q8TF65 GIPC2 Homo sapiens Q8TF65
Y2H Prey Pooling
32296183
Intra
GIPC2 Q8TF65 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
GIPC2 Q8TF65 SP100 Homo sapiens P23497
Y2H Array
25416956
Intra
GIPC2 Q8TF65 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Array
32296183
Intra
GIPC2 Q8TF65 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GIPC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89726 GIPC2 Antibody (YA9070) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Waardenburg Syndrome, Type 4a

  • Waardenburg-Shah Syndrome

  • Shah-Waardenburg Syndrome

  • Waardenburg Syndrome Type 4a

  • WS4A

  • Ws4

  • Waardenburg Syndrome Type 4

  • Waardenburg Syndrome Type Iva

  • Waardenburg Syndrome With Hirschsprung Disease Type 4a

  • Hirschsprung Disease With Pigmentary Anomaly

  • Waardenburg-Hirschsprung Syndrome

  • Waardenburg Syndrome, Type Iva

  • Waardenburg Syndrome With Hirschsprung Disease, Type 4a

  • Waardenburg-Hirschsprung Disease

  • Waardenburg Syndrome, Type 4

  • Waardenburg Syndrome 4a
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05436 GIPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GIPC2 RGD RGD:1560751
Felis catus GIPC2 VGNC VGNC:80219
Bos taurus GIPC2 VGNC VGNC:29366
Macaca mulatta GIPC2 VGNC VGNC:106370
Mus musculus GIPC2 MGD MGI:1889209
Canis familiaris GIPC2 VGNC VGNC:41226
Others GIPC2 NCBI