PLEKHA2 - pleckstrin homology domain containing A2 Gene

Also Known as TAPP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59339

Summary

Enables fibronectin binding activity; laminin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in positive regulation of cell-matrix adhesion. Located in cytoplasm and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in lymph node (RPKM 32.5), spleen (RPKM 19.2) and 23 other tissues.

PLEKHA2 Products (2)

mRNA Protein Name
NM_001410925.1 NP_001397854.1 pleckstrin homology domain-containing family A member 2 isoform 2
NM_021623.2 NP_067636.1 pleckstrin homology domain-containing family A member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IMP
IMP: Inferred from mutant phenotype
19786618 GOA
enables laminin binding IMP
IMP: Inferred from mutant phenotype
19786618 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
11001876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19786618 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
19786618 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19786618 GOA
located in membrane IDA
IDA: Inferred from direct assay
19786618 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
19786618 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLEKHA2 Q9HB19 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 EGLN3 Homo sapiens Q9H6Z9
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 EGLN3 Homo sapiens Q9H6Z9
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GIPC3 Homo sapiens Q8TF64
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 GIPC3 Homo sapiens Q8TF64
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 SNTG1 Homo sapiens Q9NSN8
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 SNTG1 Homo sapiens Q9NSN8
Validated Y2H
32296183
Intra
PLEKHA2 Q9HB19 SNTG1 Homo sapiens Q9NSN8
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GIPC1 Homo sapiens O14908
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 GIPC1 Homo sapiens O14908
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra
PLEKHA2 Q9HB19 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GIPC2 Homo sapiens Q8TF65
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 GIPC2 Homo sapiens Q8TF65
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 M1AP Homo sapiens Q8TC57
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 M1AP Homo sapiens Q8TC57
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 DLG2 Homo sapiens Q15700
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
Intra
PLEKHA2 Q9HB19 DLG3 Homo sapiens Q92796
Y2H Array
32296183
Intra
PLEKHA2 Q9HB19 DLG3 Homo sapiens Q92796
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10682 PLEKHA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10679 PLEKHA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10680 PLEKHA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10681 PLEKHA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10683 PLEKHA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10684 PLEKHA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10686 PLEKHB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10688 PLEKHF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10690 PLEKHG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10696 PLEKHH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10698 PLEKHM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10701 PLEKHO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown