M1AP - meiosis 1 associated protein Gene

Also Known as D6Mm5e; SPGF48; C2orf65; SPATA37

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 130951

About M1AP

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,557,883-74,648,330 (from NCBI)

This gene has 9 transcripts (splice variants), 174 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 3.3), bone marrow (RPKM 2.4) and 8 other tissues.

Summary

This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

M1AP Products (4)

mRNA Protein Name
NM_001281295.2 NP_001268224.1 meiosis 1 arrest protein isoform 2
NM_001281296.2 NP_001268225.1 meiosis 1 arrest protein isoform 3
NM_001321739.2 NP_001308668.1 meiosis 1 arrest protein isoform 1
NM_138804.5 NP_620159.2 meiosis 1 arrest protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
32673564 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

meiosis 1 arrest protein

  • meiosis 1 arresting protein

M1AP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
M1AP Q8TC57 DES Homo sapiens P17661
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 DES Homo sapiens P17661
Y2H Array
32296183
Intra
M1AP Q8TC57 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32296183
Intra
M1AP Q8TC57 POLR3GL Homo sapiens Q9BT43
Validated Y2H
32296183
Intra
M1AP Q8TC57 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
M1AP Q8TC57 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Intra
M1AP Q8TC57 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
M1AP Q8TC57 PLEKHA2 Homo sapiens Q9HB19
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 PLEKHA2 Homo sapiens Q9HB19
Validated Y2H
32296183
Intra
M1AP Q8TC57 PLEKHA2 Homo sapiens Q9HB19
Y2H Array
32296183
Intra
M1AP Q8TC57 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
M1AP Q8TC57 BAHD1 Homo sapiens Q8TBE0
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 BAHD1 Homo sapiens Q8TBE0
Y2H Array
32296183
Intra
M1AP Q8TC57 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 CRX Homo sapiens O43186
Y2H Array
32296183
Intra
M1AP Q8TC57 M1AP Homo sapiens Q8TC57
Validated Y2H
32296183
Intra
M1AP Q8TC57 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 M1AP Homo sapiens Q8TC57
Y2H Prey Pooling
32296183
Intra
M1AP Q8TC57 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
M1AP Q8TC57 M1AP Homo sapiens Q8TC57
Y2H Array
25416956
Intra
M1AP Q8TC57 M1AP Homo sapiens Q8TC57
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 48

  • SPGF48
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07936 M1AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18039 M1ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24513 M1ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus M1AP MGD MGI:1315200
Canis familiaris M1AP VGNC VGNC:42907
Bos taurus M1AP VGNC VGNC:31124
Rattus norvegicus M1AP RGD RGD:1563842
Felis catus M1AP VGNC VGNC:63355
Macaca mulatta M1AP VGNC VGNC:74354
Others M1AP NCBI