DLG2 - discs large MAGUK scaffold protein 2 Gene

Also Known as PSD93; PSD-93; PPP1R58; chapsyn-110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1740

About DLG2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:83,455,012-85,628,373 (from NCBI)

This gene has 50 transcripts (splice variants), 219 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.7), adrenal (RPKM 2.3) and 5 other tissues.

Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

DLG2 Products (26)

mRNA Protein Name
NM_001142699.3 NP_001136171.1 disks large homolog 2 isoform 1
NM_001142700.2 NP_001136172.1 disks large homolog 2 isoform 3
NM_001142702.2 NP_001136174.1 disks large homolog 2 isoform 4
NM_001206769.2 NP_001193698.1 disks large homolog 2 isoform 5
NM_001300983.1 NP_001287912.1 disks large homolog 2 isoform 6
NM_001351274.2 NP_001338203.1 disks large homolog 2 isoform 7
NM_001351275.2 NP_001338204.1 disks large homolog 2 isoform 8
NM_001351276.2 NP_001338205.1 disks large homolog 2 isoform 9
NM_001364.3 NP_001355.2 disks large homolog 2 isoform 2
NM_001377966.1 NP_001364895.1 disks large homolog 2 isoform 10
NM_001377967.1 NP_001364896.1 disks large homolog 2 isoform 11
NM_001377968.1 NP_001364897.1 disks large homolog 2 isoform 12
NM_001377970.1 NP_001364899.1 disks large homolog 2 isoform 13
NM_001377971.1 NP_001364900.1 disks large homolog 2 isoform 14
NM_001377972.1 NP_001364901.1 disks large homolog 2 isoform 15
NM_001377973.1 NP_001364902.1 disks large homolog 2 isoform 16
NM_001377974.1 NP_001364903.1 disks large homolog 2 isoform 17
NM_001377975.1 NP_001364904.1 disks large homolog 2 isoform 18
NM_001377976.1 NP_001364905.1 disks large homolog 2 isoform 19
NM_001377977.1 NP_001364906.1 disks large homolog 2 isoform 20
NM_001377978.1 NP_001364907.1 disks large homolog 2 isoform 21
NM_001377979.1 NP_001364908.1 disks large homolog 2 isoform 22
NM_001377980.1 NP_001364909.1 disks large homolog 2 isoform 23
NM_001377981.1 NP_001364910.1 disks large homolog 2 isoform 24
NM_001377982.1 NP_001364911.1 disks large homolog 2 isoform 25
NM_001377983.1 NP_001364912.1 disks large homolog 2 isoform 26

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables kinase binding IDA
IDA: Inferred from direct assay
21119615 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15304517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLG2 Protein Structure

MAGUK_N_PEST

MAGUK_N_PEST: Polyubiquitination (PEST) N-terminal domain of MAGUK (14 - 97)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (98 - 181)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (194 - 276)

PDZ_assoc

PDZ_assoc: PDZ-associated domain of NMDA receptors (278 - 345)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (422 - 497)

SH3_2

SH3_2: Variant SH3 domain (540 - 599)

Guanylate_kin

Guanylate_kin: Guanylate kinase (680 - 856)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 870 a.a.
Protein Preferred Names Protein Names

disks large homolog 2

  • channel-associated protein of synapse-110

DLG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DLG2 Q15700 RPF2 Homo sapiens Q9H7B2
Validated Y2H
32296183
Intra
DLG2 Q15700 FA2H Homo sapiens Q7L5A8
Validated Y2H
32296183
Intra
DLG2 Q15700 DLGAP1 Homo sapiens Q6IS01
Validated Y2H
32296183
Intra
DLG2 Q15700 DLGAP2 Homo sapiens Q9P1A6-3
Validated Y2H
32296183
Intra
DLG2 Q15700 PPIL4 Homo sapiens Q8WUA2
Validated Y2H
32296183
Intra
DLG2 Q15700 SERPINB13 Homo sapiens Q9UIV8
Validated Y2H
32296183
Intra
DLG2 Q15700 PLEKHA2 Homo sapiens Q9HB19
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

DLG2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83442 PSD93 Antibody (YA3187) WB, FC Human, Mouse, Rat
HY-P83442A PSD93 Antibody (YA3187)(PBS only) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Childhood Osteosarcoma

  • Pediatric Osteosarcoma
Coffin-Siris Syndrome 1

  • Coffin-Siris Syndrome

  • Fifth Digit Syndrome

  • Css

  • CSS1

  • Mrd12

  • Mental Retardation, Autosomal Dominant 12

  • Hhid

  • Dwarfism-Onychodysplasia

  • Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

  • Autosomal Dominant Mental Retardation 12

  • Short Stature-Onychodysplasia.

  • Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

  • Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

  • Short Stature-Onychodysplasia

  • Coffin-Siris Syndrome, Type 1

  • Mental Retardation, Autosomal Dominant, Type 12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03797 DLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08623 MPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19354 Mpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25845 Mpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DLG2 MGD MGI:1344351
Rattus norvegicus DLG2 RGD RGD:619895
Macaca mulatta DLG2 VGNC VGNC:81388
Canis familiaris DLG2 VGNC VGNC:39978
Others DLG2 NCBI