PSD93 Antibody (YA3187)
(Synonyms: DLG2; Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93)PSD93 Antibody (YA3187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSD93.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:100-1:500 |
Product Details
PSD93 Antibody (YA3187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSD93.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 98 kDa
Entrez Gene: 1740 Human ; 23859 Mouse ; 64053 Rat
SwissProt: Q15700 Human ; Q91XM9 Mouse ; Q63622 Rat
OMIM: 603583 Human
A synthetic peptide of human PSD93 aa 621-634.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSD93 is required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses
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Subcellular Localization
Cell membrane; Lipid-anchor; Postsynaptic density; Synapse; Membrane; Cell projection, axon; Perikaryon
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Isoforms & Post-Translational Modification
Q15700 has 5 isomers: Q15700-1: 97552 Da (predicted); Q15700-2: 109371 Da (predicted); Q15700-3: 83405 Da (predicted); Q15700-4: 100981 Da (predicted); Q15700-5: 38404 Da (predicted).
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density -
Subunit
Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains (PubMed:15304517). Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with FASLG (PubMed:19807924). Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity). Interacts with DGKI (via PDZ-binding motif) (By similarity)
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SwissProt ID
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Synonyms
DLG2; Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93
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Research Field
Neuroscience
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