SERPINB13 - serpin family B member 13 Gene

Also Known as HUR7; PI13; headpin; HSHUR7SEQ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5275

About SERPINB13

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,587,343-63,599,192 (from NCBI)

This gene has 6 transcripts (splice variants), 82 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 94.0).

Summary

The protein encoded by this gene is a member of the Serpin family of serine Protease Inhibitors. The encoded protein inhibits the activity of Cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of Cancer. [provided by RefSeq, Jan 2017]

SERPINB13 Products (6)

mRNA Protein Name
NM_001307923.2 NP_001294852.1 serpin B13 isoform 1
NM_001348267.2 NP_001335196.1 serpin B13 isoform 3
NM_001348268.2 NP_001335197.1 serpin B13 isoform 3
NM_001348269.2 NP_001335198.1 serpin B13 isoform 4
NM_001348270.2 NP_001335199.1 serpin B13 isoform 4
NM_012397.4 NP_036529.1 serpin B13 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
12504904 GOA
enables cysteine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
12809493 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
12504904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
NOT enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
12504904 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
12504904 GOA
involved in negative regulation of keratinocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
12809493 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12809493 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
12809493 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
12809493 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB13 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (8 - 391)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

serpin B13

  • HURPIN

SERPINB13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERPINB13 Q9UIV8 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
Intra
SERPINB13 Q9UIV8 DLG2 Homo sapiens Q15700
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12709 SERPINB13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SERPINB13 VGNC VGNC:34472
Macaca mulatta SERPINB13 VGNC VGNC:104246
Mus musculus SERPINB13 MGD MGI:3042250
Canis familiaris SERPINB13 VGNC VGNC:46029
Rattus norvegicus SERPINB13 RGD RGD:1304661