SP100 - SP100 nuclear antigen Gene

Homo sapiens

Also known as lysp100b

Gene ID: 6672 | Gene type: protein coding

About SP100

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,416,201-230,545,606 (from NCBI)

This gene has 19 transcripts (splice variants), 252 orthologues and 20 paralogues. Ubiquitous expression in lymph node (RPKM 13.9), bone marrow (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

SP100 Products(6)

mRNA	Protein	Name
NM_001080391.2	NP_001073860.1	nuclear autoantigen Sp-100 isoform 1
NM_001206701.2	NP_001193630.1	nuclear autoantigen Sp-100 isoform 3
NM_001206702.2	NP_001193631.1	nuclear autoantigen Sp-100 isoform 4
NM_001206703.2	NP_001193632.1	nuclear autoantigen Sp-100 isoform 5
NM_001206704.2	NP_001193633.1	nuclear autoantigen Sp-100 isoform 6
NM_003113.4	NP_003104.2	nuclear autoantigen Sp-100 isoform 2

SP100 Protein Structure

HSR

SAND

HMG_box_2

HMG_box

0
200
400
600
800
879 a.a.

Protein Preferred Names

Protein Names

nuclear autoantigen Sp-100

SP100-HMG nuclear autoantigen

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Cholangitis

Acute Cholangiolitis	Ascending Cholangitis
Cholangiolitis	Cholangitis Nos
Chronic Cholangiolitis	Hepatic Duct Inflammation
Acute Cholangitis	Bile Duct Inflammation

Chronic Cholangitis

Autoimmune Cholangitis

Autoimmune Cholangiopathy

Crest Syndrome

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Amelogenesis Imperfecta, Type Ie

Aih1	Amelogenesis Imperfecta Type 1e
AI1E	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth	Enamel Hypoplasia, X-Linked
Amelogenesis Imperfecta Type Ie	Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1
Enamel Hypoplasia X-Linked	Amelogenesis Imperfecta, X-Linked 1
Amelogenesis Imperfecta, Type 1e	Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth
X-Linked Amelogenesis Imperfecta 1	X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta X-Linked 1
Amelogenesis Imperfecta 1e	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e
Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth	Xai
X-Linked Amelogenesis Imperfecta	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Suppurative Cholangitis

Meckel Syndrome, Type 7

Meckel Syndrome 7	Nphp3-Related Meckel-Like Syndrome
MKS7	Goldston Syndrome
Meckel Syndrome Type 7	Meckel-Like Syndrome Type 1
Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome	Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst
Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst	Meckel-Gruber Syndrome, Type 7
Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0084A	Procainamide		95.31%	Unkown
HY-A0084	Procainamide hydrochloride	Inducer	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-A0084S	Procainamide-d4 hydrochloride	/	Unkown
HY-A0084S1	Procainamide-13C2 hydrochloride	/	Unkown
HY-RS13601	SP100 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SP100	MGD	MGI:109561
Rattus norvegicus	SP100	RGD	RGD:1359550
Canis familiaris	SP100	VGNC	VGNC:59095

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