CASP8AP2 - caspase 8 associated protein 2 Gene

Homo sapiens

Also known as CED-4; FLASH; RIP25

Gene ID: 9994 | Gene type: protein coding

About CASP8AP2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,829,880-89,874,436 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 203 orthologues. Ubiquitous expression in lymph node (RPKM 5.6), testis (RPKM 4.6) and 25 other tissues.

Summary

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of Caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas Receptor, Fas-binding adapter FADD, and Caspase 8, and plays a regulatory role in Fas-mediated Apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]

CASP8AP2 Products(3)

mRNA	Protein	Name
NM_001137667.2	NP_001131139.1	CASP8-associated protein 2
NM_001137668.2	NP_001131140.1	CASP8-associated protein 2
NM_012115.4	NP_036247.1	CASP8-associated protein 2

Protein Preferred Names

Protein Names

CASP8-associated protein 2

FLASH homolog RIP25

Related Diseases

Diseases

Alias

Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type	Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Atr Syndrome Linked To Chromosome 16	Atr Syndrome, Deletion Type
Atr-16 Syndrome	Alpha Thalassemia-Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type	Alpha-Thalassemia/Mental Retardation Syndrome, Type 1
Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CASP8AP2	VGNC	VGNC:26785
Rattus norvegicus	CASP8AP2	RGD	RGD:1305771
Felis catus	CASP8AP2	VGNC	VGNC:60385
Macaca mulatta	CASP8AP2	VGNC	VGNC:70548
Canis familiaris	CASP8AP2	VGNC	VGNC:38737
Mus musculus	CASP8AP2	MGD	MGI:1349399

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