PIAS1 - protein inhibitor of activated STAT 1 Gene

Also Known as GBP; ZMIZ3; DDXBP1; GU/RH-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8554

About PIAS1

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,054,315-68,193,847 (from NCBI)

This gene has 8 transcripts (splice variants), 297 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 Ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PIAS1 Products (2)

mRNA	Protein	Name
NM_001320687.1	NP_001307616.1	E3 SUMO-protein ligase PIAS1 isoform 1
NM_016166.3	NP_057250.1	E3 SUMO-protein ligase PIAS1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	18579533	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	12356736	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	17087506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14752048	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	36050397	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	17696781	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	18579533	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	14752048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS1 Protein Structure

PINIT

zf-MIZ

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names	Protein Names
E3 SUMO-protein ligase PIAS1	AR interacting protein

PIAS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PIAS1	O75925	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	PIAS1	O75925	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	PIAS1	O75925	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	PIAS1	O75925	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	PIAS1	O75925	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	PIAS1	O75925	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	PIAS1	O75925	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	PIAS1	O75925	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	PIAS1	O75925	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	PIAS1	O75925	PPT1	Homo sapiens	P50897	Y2H Array	32814053
Intra	PIAS1	O75925	PPT1	Homo sapiens	P50897	Validated Y2H	32814053
Intra	PIAS1	O75925	PPT1	Homo sapiens	P50897	Y2H Pooling	32814053
Intra	PIAS1	O75925	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	PIAS1	O75925	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	PIAS1	O75925	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	PIAS1	O75925	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	PIAS1	O75925	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	PIAS1	O75925	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	PIAS1	O75925	CASP8AP2	Homo sapiens	Q9UKL3	Y2H	21338522
Intra	PIAS1	O75925	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	PIAS1	O75925	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	PIAS1	O75925	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	PIAS1	O75925	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	PIAS1	O75925	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	PIAS1	O75925	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	PIAS1	O75925	TP53	Homo sapiens	P04637	Pull Down	15133049
Intra	PIAS1	O75925	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	PIAS1	O75925	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	PIAS1	O75925	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	PIAS1	O75925	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PIAS1	O75925	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PIAS1	O75925	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PIAS1	O75925	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	PIAS1	O75925	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	PIAS1	O75925	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	PIAS1	O75925	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	PIAS1	O75925	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	PIAS1	O75925	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	PIAS1	O75925	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	PIAS1	O75925	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	PIAS1	O75925	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	PIAS1	O75925	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	PIAS1	O75925	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	PIAS1	O75925	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	PIAS1	O75925	SNCB	Homo sapiens	Q16143	Y2H Pooling	32814053
Intra	PIAS1	O75925	SNCB	Homo sapiens	Q16143	Validated Y2H	32814053
Intra	PIAS1	O75925	SNCB	Homo sapiens	Q16143	Y2H Array	32814053
Intra	PIAS1	O75925	ASPA	Homo sapiens	P45381	Validated Y2H	32814053
Intra	PIAS1	O75925	ASPA	Homo sapiens	P45381	Y2H Array	32814053
Intra	PIAS1	O75925	ASPA	Homo sapiens	P45381	Y2H Pooling	32814053
Intra	PIAS1	O75925	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	PIAS1	O75925	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	PIAS1	O75925	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	PIAS1	O75925	MBD1	Homo sapiens	Q9UIS9	Anti Bait CoIP	17066076
Intra	PIAS1	O75925	MBD1	Homo sapiens	Q9UIS9	Pull Down	17066076
Intra	PIAS1	O75925	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PIAS1	O75925	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PIAS1	O75925	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
Intra	PIAS1	O75925	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PIAS1	O75925	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053
Intra	PIAS1	O75925	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	PIAS1	O75925	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	PIAS1	O75925	PRDM1	Homo sapiens	O75626	Anti Bait CoIP	22555612
Intra	PIAS1	O75925	PRDM1	Homo sapiens	O75626	Anti Tag CoIP	22555612
Intra	PIAS1	O75925	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	PIAS1	O75925	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	PIAS1	O75925	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	PIAS1	O75925	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	PIAS1	O75925	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	PIAS1	O75925	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Cross	PIAS1	O75925	P29991-PRO_0000037946	Dengue virus type 2	P29991-PRO_0000037946	Y2H	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

PIAS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82472	PIAS1 Antibody (YA2217)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82730	PIAS1/2 Antibody (YA2475)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Borderline Glaucoma	Preglaucoma
Unilateral Focal Polymicrogyria
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W062696	BC-1382	Inhibitor	99.36%	Unkown
HY-RS10473	PIAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20081	Pias1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26584	Pias1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIAS1	VGNC	VGNC:75876
Rattus norvegicus	PIAS1	RGD	RGD:1307843
Bos taurus	PIAS1	VGNC	VGNC:32856
Mus musculus	PIAS1	MGD	MGI:1913125
Felis catus	PIAS1	VGNC	VGNC:64159
Canis familiaris	PIAS1	VGNC	VGNC:44519
Others	PIAS1	NCBI