DYRK2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

Homo sapiens

Gene ID: 8445 | Gene type: protein coding

About DYRK2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:67,648,745-67,665,406 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 12 paralogues. Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.4) and 25 other tissues.

Summary

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

DYRK2 Products(3)

mRNA	Protein	Name
XM_017020032.2	XP_016875521.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1
NM_003583.4	NP_003574.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
NM_006482.3	NP_006473.2	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

DYRK2 Protein Structure

Pkinase

0
100
200
300
400
500
601 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 2

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Related Diseases

Diseases

Alias

Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b	WS2B
Waardenburg Syndrome, Type Iib	Waardenburg Syndrome Type Iib

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112296	T025	Inhibitor	98.84%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK2	MGD	MGI:1330301
Felis catus	DYRK2	VGNC	VGNC:61687
Bos taurus	DYRK2	VGNC	VGNC:55902
Rattus norvegicus	DYRK2	RGD	RGD:1312039
Macaca mulatta	DYRK2	VGNC	VGNC:72018
Canis familiaris	DYRK2	VGNC	VGNC:40157
Others	DYRK2	NCBI

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