DYRK2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8445

About DYRK2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:67,648,745-67,665,406 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 12 paralogues. Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.4) and 25 other tissues.

Summary

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

DYRK2 Products (3)

mRNA	Protein	Name
XM_017020032.2	XP_016875521.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1
NM_003583.4	NP_003574.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
NM_006482.3	NP_006473.2	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11311121	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9748265	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	9748265	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23602568	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11311121	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9748265	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IEP IEP: Inferred from expression pattern	19965871	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	17349958	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	16511445	GOA
involved in positive regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	11311121	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11311121	GOA
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18455992	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17349958	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17349958	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19287380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK2 Protein Structure

Pkinase

0
100
200
300
400
500
601 a.a.

Protein Preferred Names	Protein Names
dual specificity tyrosine-phosphorylation-regulated kinase 2	dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2

DYRK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DYRK2	Q92630	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	DYRK2	Q92630	DYRK4	Homo sapiens	Q9NR20	Anti Tag CoIP	23602568
Intra	DYRK2	Q92630	DYRK4	Homo sapiens	Q9NR20	TAP	23602568
Intra	DYRK2	Q92630	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	25416956
Intra	DYRK2	Q92630	WDR62	Homo sapiens	O43379	Y2H Prey Pooling	25416956
Intra	DYRK2	Q92630	WDR62	Homo sapiens	O43379	Validated Y2H	25416956
Intra	DYRK2	Q92630	KXD1	Homo sapiens	Q9BQD3	Y2H Array	25416956
Intra	DYRK2	Q92630	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	DYRK2	Q92630	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	DYRK2	Q92630	SP100	Homo sapiens	P23497	Validated Y2H	25416956
Intra	DYRK2	Q92630	SP100	Homo sapiens	P23497	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Waardenburg Syndrome, Type 2b	Waardenburg Syndrome Type 2b WS2B Waardenburg Syndrome, Type Iib Waardenburg Syndrome Type Iib
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105309	GSK-626616	Inhibitor	99.88%	Unkown
HY-112296	T025	Inhibitor	99.64%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	98.0%	Unkown
HY-117049	Leucettine L41	Inhibitor	98.98%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.06%	Unkown
HY-153949	YK-2-69	Inhibitor	99.57%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.30%	Unkown
HY-125290	MU1210	Inhibitor	99.50%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-13455	LDN-192960	Inhibitor	99.58%	Unkown
HY-156816	ON 108600	Inhibitor	98.65%	Unkown
HY-13455A	LDN-192960 hydrochloride	Inhibitor	99.83%	Unkown
HY-162750	ZJCK-6-46	Inhibitor	99.06%	Unkown
HY-110320	LDN-209929 dihydrochloride	Inhibitor	98.33%	Unkown
HY-161597	PROTAC DYRK2 degrader 1	Degrader	/	Unkown
HY-402805	DYRK2-IN-2	Inhibitor	/	Unkown
HY-402805A	DYRK2-IN-2 hydrochloride	Inhibitor	/	Unkown
HY-172198	GSK3-IN-10	Inhibitor	/	Unkown
HY-177416	MU1787	Inhibitor	99.84%	Unkown
HY-161598	DYRK2 ligand 1	Degrader	/	Unkown
HY-181085	RD0448	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DYRK2	MGD	MGI:1330301
Felis catus	DYRK2	VGNC	VGNC:61687
Bos taurus	DYRK2	VGNC	VGNC:55902
Rattus norvegicus	DYRK2	RGD	RGD:1312039
Macaca mulatta	DYRK2	VGNC	VGNC:72018
Canis familiaris	DYRK2	VGNC	VGNC:40157
Others	DYRK2	NCBI