1. Cell Cycle/DNA Damage
    Protein Tyrosine Kinase/RTK
  2. Haspin Kinase
    DYRK
  3. LDN-192960

LDN-192960 

Cat. No.: HY-13455 Purity: 99.56%
Handling Instructions

LDN-192960 is a dual inhibitor of Haspin and dual-specificity tyrosine-regulated Kinase (DYRK2) with IC50s of 10 nM and 48 nM, respectively.

For research use only. We do not sell to patients.

LDN-192960 Chemical Structure

LDN-192960 Chemical Structure

CAS No. : 184582-62-5

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Description

LDN-192960 is a dual inhibitor of Haspin and dual-specificity tyrosine-regulated Kinase (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

IC50 & Target

IC50: 0.21 μM (CLK1); 0.10 μM (DYRK1A); 2 nM (DYRK2); 19 nM (DYRK3); 1.6 μM (ROS); 1.4 μM (HIPK1); 1.3 μM (HIPK2); 0.72 μM (PIM1); 56 μM (PIM2)[1]

Molecular Weight

328.43

Formula

C₁₈H₂₀N₂O₂S

CAS No.

184582-62-5

SMILES

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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LDN-192960
Cat. No.:
HY-13455
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