1. Cell Cycle/DNA Damage
    Protein Tyrosine Kinase/RTK
  2. Haspin Kinase
    DYRK
    CDK
    ROS
  3. LDN-192960 hydrochloride

LDN-192960 hydrochloride 

Cat. No.: HY-13455A
Handling Instructions

LDN-192960 hydrochloride is a dual inhibitor of Haspin and dual-specificity tyrosine-regulated Kinase (DYRK2) with IC50s of 10 nM and 48 nM, respectively.

For research use only. We do not sell to patients.

LDN-192960 hydrochloride Chemical Structure

LDN-192960 hydrochloride Chemical Structure

CAS No. : 2309172-48-1

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of LDN-192960 hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LDN-192960 hydrochloride is a dual inhibitor of Haspin and dual-specificity tyrosine-regulated Kinase (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

IC50 & Target

IC50: 0.21 μM (CLK1); 0.10 μM (DYRK1A); 2 nM (DYRK2); 19 nM (DYRK3); 1.6 μM (ROS); 1.4 μM (HIPK1); 1.3 μM (HIPK2); 0.72 μM (PIM1); 56 μM (PIM2)[1]

Molecular Weight

401.35

Formula

C₁₈H₂₂Cl₂N₂O₂S

CAS No.

2309172-48-1

SMILES

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LDN-192960 hydrochloride
Cat. No.:
HY-13455A
Quantity: