PROTAC DYRK2 degrader-2
Based on 1 Customer Validation
PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3. It recruits the CRBN E3 ligase to mediate DYRK2 ubiquitination and achieves degradation via the ubiquitin-proteasome system. PROTAC DYRK2 degrader-2 downregulates the expression level of DYRK2 protein in cancer cells. It is applicable to cancer-related research.
(Pink: DYRK2 ligand (HY-186288); Blue: Cereblon ligand (HY-41547); Black: linker (HY-42776)).
For research use only. We do not sell to patients.
- Purity: 98.29%
- CAS No.: 3061366-74-0
- Formula: C42H43Cl2N5O9
- Molecular Weight:832.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
DYRK2 |
In Vitro
PROTAC DYRK2 degrader-2 (CP124) (5-10 μM; 24 h) reduces the DYRK2 protein abundance in HeLa cervical cancer cells, and its degradation activity is weaker than that of CP134, a compound from the same series[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa human cervical carcinoma cells
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Concentration:5, 10 μM
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Incubation Time:24 h
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Result:Reduced the DYRK2 protein abundance in HeLa cervical cancer cells.
Chemical Information
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CAS No. 3061366-74-0
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Appearance Solid
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Molecular Weight 832.72
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Formula C42H43Cl2N5O9
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Color Light yellow to yellow
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SMILES
O=C1C2=C(NCCOCCOCCOCCNC(CN3C/C(C(/C(C3)=C/C4=C(C=CC=C4)Cl)=O)=C\C5=C(C=CC=C5)Cl)=O)C=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC DYRK2 degrader-2 Related Classifications
HY-186287 Related Classifications
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