3061366-74-0
Chemical Structure
PROTAC DYRK2 degrader-2
- CAS. Nr.: 3061366-74-0
- Formula:C42H43Cl2N5O9
- Molecular Weight:832.72
InChIKey: MROULYJITLXYOV-KBWMUOTDSA-N
SMILES: O=C1C2=C(NCCOCCOCCOCCNC(CN3C/C(C(/C(C3)=C/C4=C(C=CC=C4)Cl)=O)=C\C5=C(C=CC=C5)Cl)=O)C=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
Biological Activity: PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3. It recruits the CRBN E3 ligase to mediate DYRK2 ubiquitination and achieves degradation via the ubiquitin-proteasome system. PROTAC DYRK2 degrader-2 downregulates the expression level of DYRK2 protein in cancer cells. It is applicable to cancer-related research[1].
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PROTAC DYRK2 degrader-2 | PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3. It recruits the CRBN E3 ligase to mediate DYRK2 ubiquitination and achieves degradation via the ubiquitin-proteasome system. PROTAC DYRK2 degrader-2 downregulates the expression level of DYRK2 protein in cancer cells. It is applicable to cancer-related research. | |||||||||||||||||||||
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Keywords
