DYRK2 ligand 2
DYRK2 ligand 2 is a curcumin analog and an inhibitor targeting DYRK2, which serves as a ligand for target protein for PROTAC against DYRK2. DYRK2 ligand 2 is applicable to studies related to PROTAC synthesis, such as for PROTAC DYRK2 degrader-2 (HY-186287).
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- No. CAS: 3061366-78-4
- Fòrmula: C21H17Cl2NO3
- Peso molecular:402.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
DYRK2 19 nM (IC50) |
DYRK2 4.7 μM (Kd) |
In Vitro
DYRK2 ligand 2 can be used to synthesize PROTAC DYRK2 degrader-2 (HY-186287). PROTAC DYRK2 degrader-2 is a PROTAC-based DYRK2 degrader derived from curcumin analog A3. It recruits the CRBN E3 ligase to mediate the ubiquitination of DYRK2, leading to degradation via the ubiquitin-proteasome system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3061366-78-4
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Peso molecular 402.27
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Fòrmula C21H17Cl2NO3
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SMILES
OC(CN1C/C(C(/C(C1)=C/C2=C(C=CC=C2)Cl)=O)=C\C3=C(C=CC=C3)Cl)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DYRK2 ligand 2 Related Classifications
HY-186288 Related Classifications
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