DYRK2 ligand 2
DYRK2 ligand 2 is a curcumin analog and an inhibitor targeting DYRK2, which serves as a ligand for target protein for PROTAC against DYRK2. DYRK2 ligand 2 is applicable to studies related to PROTAC synthesis, such as for PROTAC DYRK2 degrader-2 (HY-186287).
For research use only. We do not sell to patients.
- CAS No.: 3061366-78-4
- Formula: C21H17Cl2NO3
- Molecular Weight:402.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DYRK2 19 nM (IC50) |
DYRK2 4.7 μM (Kd) |
DYRK2 ligand 2 (compound 8A2) binds to purified DYRK2 protein with a Kd value of 4.7 μM, and inhibits the kinase activity of purified DYRK2 with an IC50 of 19 nM[1].
DYRK2 ligand 2 can be used to synthesize PROTAC DYRK2 degrader-2 (HY-186287). PROTAC DYRK2 degrader-2 is a PROTAC-based DYRK2 degrader derived from curcumin analog A3. It recruits the CRBN E3 ligase to mediate the ubiquitination of DYRK2, leading to degradation via the ubiquitin-proteasome system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3061366-78-4
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Molecular Weight 402.27
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Formula C21H17Cl2NO3
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SMILES
OC(CN1C/C(C(/C(C1)=C/C2=C(C=CC=C2)Cl)=O)=C\C3=C(C=CC=C3)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DYRK2 ligand 2 Related Classifications
HY-186288 Related Classifications
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