PROTAC DYRK2 degrader 1
PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC50 values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer.
(Pink: DYRK2 ligand (HY-161598); Blue: Cereblon ligand (HY-10984); Black: linker (HY-42776)).
For research use only. We do not sell to patients.
- CAS No.: 3061366-76-2
- Formula: C42H43Br2N5O9
- Molecular Weight:921.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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DYRK2 1.607 μM (DC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
9.1 μM
Compound: CP134
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
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[PMID: 38746900] |
Chemical Information
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CAS No. 3061366-76-2
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Molecular Weight 921.63
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Formula C42H43Br2N5O9
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SMILES
O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4C/C(C(/C(C4)=C/C5=CC=CC=C5Br)=O)=C\C6=CC=CC=C6Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC DYRK2 degrader 1 Related Classifications
HY-161597 Related Classifications
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