2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs DYRK
  4. PROTAC DYRK2 degrader 1

PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC50 values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer.
(Pink: DYRK2 ligand (HY-161598); Blue: Cereblon ligand (HY-10984); Black: linker (HY-42776)).

For research use only. We do not sell to patients.

PROTAC DYRK2 degrader 1

PROTAC DYRK2 degrader 1 Chemical Structure

CAS No. : 3061366-76-2

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PROTAC DYRK2 degrader 1 Related Antibodies

Top Publications Citing Use of Products

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Description

PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC50 values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer[1]. (Pink: DYRK2 ligand (HY-161598); Blue: Cereblon ligand (HY-10984); Black: linker (HY-42776)).

IC50 & Target[1]

DYRK2

1.607 μM (DC50)

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
9.1 μM
Compound: CP134
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay
[PMID: 38746900]
In Vitro

PROTAC DYRK2 degrader 1 (Compound CP134) inhibits MDA-MB-231 cell proliferation with an IC50 of 9.1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC DYRK2 degrader 1 Related Antibodies
Molecular Weight

921.63

Formula

C42H43Br2N5O9
CAS No.
SMILES

O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4C/C(C(/C(C4)=C/C5=CC=CC=C5Br)=O)=C\C6=CC=CC=C6Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC DYRK2 degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC DYRK2 degrader 13061366-76-2PROTACsDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCRBN E3 ligaseprostate cancermultiple myelomacervical carcinomaMDA-MB-231 cellsubiquitin?proteasome systemphosphorylated p53 (Ser46)triple-negative breast cancerHeLa cellsDYRK2Inhibitorinhibitorinhibit

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