3061366-76-2
3061366-76-2
Chemical Structure
PROTAC DYRK2 degrader 1
- CAS No.: 3061366-76-2
- Formula:C42H43Br2N5O9
- Molecular Weight:921.63
InChIKey: MSJQVDOQEDVIAO-KBWMUOTDSA-N
SMILES: O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4C/C(C(/C(C4)=C/C5=CC=CC=C5Br)=O)=C\C6=CC=CC=C6Br
Biological Activity: PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC50 values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer[1].
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PROTAC DYRK2 degrader 1 | 90.63% | PROTAC DYRK2 degrader 1 is a DYRK2 PROTAC degrader with DC50 values of 1.607 μM (MDA-MB-231 cells) and 3.265 μM (HeLa cells), respectively. PROTAC DYRK2 degrader 1 induces DYRK2 degradation via the ubiquitin-proteasome system. It is applicable to the research of triple-negative breast cancer and cervical cancer. | ||||||||||||||||||||
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