2. Gene
  3. DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8798 | Gene type: protein coding

About DYRK4

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,562,208-4,613,875 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 12 paralogues. Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes an Enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

DYRK4 Products(7)

mRNA Protein Name
NM_001282285.3 NP_001269214.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2
NM_001282286.2 NP_001269215.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3
NM_001371301.2 NP_001358230.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4
NM_001394779.1 NP_001381708.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5
NM_001394780.1 NP_001381709.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6
NM_001407019.1 NP_001393948.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1
NM_003845.3 NP_003836.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1

DYRK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (104 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 4

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7

Mental Retardation, Autosomal Dominant 7

Autosomal Dominant Non-Syndromic Intellectual Disability 7

Dyrk1a Syndrome

Autosomal Dominant Intellectual Developmental Disorder 7

Autosomal Dominant Mental Retardation 7

Mental Retardation, Autosomal Dominant, Type 7
Abdominal Obesity-Metabolic Syndrome 3

AOMS3

Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease

Obesity, Abdominal, Metabolic Syndrome, Type 3
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DYRK4 MGD MGI:1330292
Macaca mulatta DYRK4 VGNC VGNC:97761
Bos taurus DYRK4 VGNC VGNC:55903
Felis catus DYRK4 VGNC VGNC:83870
Rattus norvegicus DYRK4 RGD RGD:1306800
Others DYRK4 NCBI