1. Cell Cycle/DNA Damage
    Protein Tyrosine Kinase/RTK
  2. Haspin Kinase
    DYRK
  3. LDN-209929 dihydrochloride

LDN-209929 dihydrochloride 

Cat. No.: HY-110320
Handling Instructions

LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455).

For research use only. We do not sell to patients.

LDN-209929 dihydrochloride Chemical Structure

LDN-209929 dihydrochloride Chemical Structure

CAS No. : 1784281-97-5

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Description

LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455)[2].

IC50 & Target

IC50: 55 nM (haspin kinase)
IC50: 9.9 μM (DYRK2)[1]

In Vitro

Haspin: Haploid Germ Cell-Specific Nuclear Protein Kinase, is a serine/threonine kinase expressed in a variety of tissues (e.g., testis, bone marrow, thymus, and spleen). Haspin also plays an important role in mitosis, where it phosphorylates histone H3 at Thr-3 (H3T3) in G2/early prophase, becomes maximal during prometaphase/metaphase and then diminishes during anaphase[1].
DYRKs belong to the CMGC family of ePKs and can be further divided into class 1 kinases DYRK1A and 1B, and class 2 kinases DYRK2, 3, and 4. The activity of DYRKs depends upon autophosphorylation of an essential activation loop tyrosine during synthesis[1].

Molecular Weight

405.77

Formula

C₁₇H₁₉Cl₃N₂OS

CAS No.

1784281-97-5

SMILES

NCCCSC1=C(C=C(Cl)C=C2)C2=NC3=CC=C(OC)C=C31.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LDN-209929LDN209929LDN 209929Haspin KinaseDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseLDN-0192960DYRK2haspin kinaseInhibitorinhibitorinhibit

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LDN-209929 dihydrochloride
Cat. No.:
HY-110320
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