1. Cell Cycle/DNA Damage
  2. CDK
  3. CLK-IN-T3

CLK-IN-T3 

Cat. No.: HY-115470
Handling Instructions

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity.

For research use only. We do not sell to patients.

CLK-IN-T3 Chemical Structure

CLK-IN-T3 Chemical Structure

CAS No. : 2109805-56-1

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Description

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1].

IC50 & Target

CLK1

0.67 nM (IC50)

CLK2

15 nM (IC50)

CLK3

110 nM (IC50)

In Vitro

CLK-IN-T3 (0.1-10.0 µM; 24 hours) results in mild cell cycle arrest at the G2/M boundary with long-duration (24 h)[1].
CLK-IN-T3 (0.5-1.0 µM; 6 hours) decreases phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly[1].
CLK-IN-T3 has IC50s of 260 nM and 230 nM for DYRK1A and DYRK1B, respectively[1].

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.1, 0.5, 1.0, 5.0, 10.0 µM
Incubation Time: 24 hours
Result: Resulted in mild cell cycle arrest at the G2/M boundary with long-duration (24 h).

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5, 1.0 μM
Incubation Time: 6 hours
Result: Decreased phosphorylation of CLK-targeted SR proteins and CLK proteins increased slightly.
Molecular Weight

482.58

Formula

C₂₈H₃₀N₆O₂

CAS No.

2109805-56-1

SMILES

CC(C1=CC=C(C(NC2=CN3C=C(C4=CC=NC=C4)C=CC3=N2)=O)C=C1)(C)C(N5CCN(C)CC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CLK-IN-T3CDKCyclin dependent kinasestableCDC-likekinaseCLKanti-canceractivityInhibitorinhibitorinhibit

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