1. Cell Cycle/DNA Damage
    Protein Tyrosine Kinase/RTK
  2. CDK
    DYRK
  3. CLK-IN-T3

CLK-IN-T3 

Cat. No.: HY-115470 Purity: 98.40%
Handling Instructions

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity.

For research use only. We do not sell to patients.

CLK-IN-T3 Chemical Structure

CLK-IN-T3 Chemical Structure

CAS No. : 2109805-56-1

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Based on 1 publication(s) in Google Scholar

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Description

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1].

IC50 & Target[1]

CLK1

0.67 nM (IC50)

CLK2

15 nM (IC50)

CLK3

110 nM (IC50)

DYRK1A

260 nM (IC50)

DYRK1B

230 nM (IC50)

In Vitro

CLK-IN-T3 inhibits DYRK1A (IC50=260 nM) and DYRK1B (IC50=230 nM)[1].
CLK-IN-T3 (0.1-10.0 µM; 24 hours) results in mild cell cycle arrest at the G2/M boundary with long-duration (24 h)[1].
CLK-IN-T3 (0.5-1.0 µM; 6 hours) decreases phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.1, 0.5, 1.0, 5.0, 10.0 µM
Incubation Time: 24 hours
Result: Resulted in mild cell cycle arrest at the G2/M boundary with long-duration (24 h).

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5, 1.0 μM
Incubation Time: 6 hours
Result: Decreased phosphorylation of CLK-targeted SR proteins and CLK proteins increased slightly.
Molecular Weight

482.58

Formula

C₂₈H₃₀N₆O₂

CAS No.

2109805-56-1

SMILES

CC(C1=CC=C(C(NC2=CN3C=C(C4=CC=NC=C4)C=CC3=N2)=O)C=C1)(C)C(N5CCN(C)CC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.83 mg/mL (10.01 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0722 mL 10.3610 mL 20.7220 mL
5 mM 0.4144 mL 2.0722 mL 4.1444 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.40%

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Keywords:

CLK-IN-T3CDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasestableCDC-likekinaseCLKanti-canceractivityDYRK1ADYRK1BInhibitorinhibitorinhibit

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Product Name:
CLK-IN-T3
Cat. No.:
HY-115470
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