Flagellin from S. typhimurium
Based on 1 Customer Validation
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 95%
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Flagellin from S. typhimurium (10 ng/mL; 10 min to 4 h) activates the NF-κB pathway in Jurkat cells, with enhanced activation observed in TLR5-overexpressing Jurkat cells[1].
Flagellin from S. typhimurium (250 ng/mL; 24 h) induces a proinflammatory response in primary chicken hepatocyte-non-parenchymal cell co-cultures by increasing IL-8 production, decreasing IL-10 production, and elevating the IFN-γ/IL-10 ratio, without causing cytotoxicity or oxidative stress[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (6-8 week-old female, subcutaneous melanoma allograft model)[1]
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Dosage:1 μg
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Administration:i.t.; single dose
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Result:Exhibited weak suppressive effect on tumor growth when used alone.
Achieved remarkable anti-tumor activity comparable to wild-type VNP20009 when combined with flagellum-deficient fliE strain, with significant tumor volume reduction relative to fliE strain alone.
Chemical Information
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Appearance Solid
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Color Colorless to light yellow
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SMILES
[Flagellin from S. typhimurium]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen J, et al. Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment. Acta Pharm Sin B. 2021 Oct;11(10):3165-3177. [Content Brief]
[2]. Tráj P, et al. Luteolin: A Phytochemical to Mitigate S. Typhimurium Flagellin-Induced Inflammation in a Chicken In Vitro Hepatic Model. Animals (Basel). 2023;13(8):1410. Published 2023 Apr 20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Flagellin from S. typhimurium Related Classifications
HY-NP134 Related Classifications
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