2. Immunology/Inflammation NF-κB
  3. Toll-like Receptor (TLR) MyD88 NF-κB Interleukin Related IFNAR
  4. Flagellin from S. typhimurium

Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases.

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Flagellin from S. typhimurium

Flagellin from S. typhimurium Chemical Structure

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Based on 1 publication(s) in Google Scholar

Flagellin from S. typhimurium Related Antibodies

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Description

Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases[1][2].

In Vitro

Flagellin from S. typhimurium (10 ng/mL; 10 min to 4 h) activates the NF-κB pathway in Jurkat cells, with enhanced activation observed in TLR5-overexpressing Jurkat cells[1].
Flagellin from S. typhimurium (250 ng/mL; 24 h) induces a proinflammatory response in primary chicken hepatocyte-non-parenchymal cell co-cultures by increasing IL-8 production, decreasing IL-10 production, and elevating the IFN-γ/IL-10 ratio, without causing cytotoxicity or oxidative stress[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flagellin from S. typhimurium Related Antibodies
In Vivo

Flagellin from S. typhimurium (1 μg; i.t.; single dose) restores the anti-tumor activity of flagellin-deficient VNP20009 in C57BL/6 mice bearing melanoma allografts, achieving efficacy comparable to that of wild-type VNP20009[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6-8 week-old female, subcutaneous melanoma allograft model)[1]
Dosage: 1 μg
Administration: i.t.; single dose
Result: Exhibited weak suppressive effect on tumor growth when used alone.
Achieved remarkable anti-tumor activity comparable to wild-type VNP20009 when combined with flagellum-deficient fliE strain, with significant tumor volume reduction relative to fliE strain alone.
Appearance

Solid

Color

Colorless to light yellow

SMILES

[Flagellin from S. typhimurium]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Flagellin from S. typhimurium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flagellin from S. typhimuriumToll-like Receptor (TLR)MyD88NF-κBInterleukin RelatedIFNARNuclear factor-κBNuclear factor-kappaBILInterferon-α/β receptorInterferon-alpha/beta receptormelanomaSalmonella typhimurium VNP20009TLR5 agonistS. typhimuriumJurkat cellsprimary chicken hepatocyte-non-parenchymal cell co-culturesC57BL/6 miceInhibitorinhibitorinhibit

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