2. Gene
  3. IRAK2 - interleukin 1 receptor associated kinase 2 Gene

IRAK2 - interleukin 1 receptor associated kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as IRAK-2

Gene ID: 3656 | Gene type: protein coding

About IRAK2

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,164,919-10,243,745 (from NCBI)

This gene has 1 transcript (splice variant), 137 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 8.0), urinary bladder (RPKM 5.9) and 22 other tissues.

Summary

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

IRAK2 Products(1)

mRNA Protein Name
NM_001570.4 NP_001561.3 interleukin-1 receptor-associated kinase-like 2

IRAK2 Protein Structure

Death

Death: Death domain (14 - 93)

Pkinase

Pkinase: Protein kinase domain (211 - 443)

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  • 625 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase-like 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06896 IRAK2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IRAK2 RGD RGD:1309584
Felis catus IRAK2 VGNC VGNC:67820
Mus musculus IRAK2 MGD MGI:2429603
Macaca mulatta IRAK2 VGNC VGNC:73758
Canis familiaris IRAK2 VGNC VGNC:103685
Bos taurus IRAK2 VGNC VGNC:30266