Sarm1 - sterile alpha and HEAT/Armadillo motif containing 1 Gene

Also Known as Sarm; MyD885; A830091I15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 237868

Summary

Enables NAD+ nucleosidase activity. Involved in NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Acts upstream of or within regulation of apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrion. Is extrinsic component of mitochondrial outer membrane. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sarm1 Products (2)

mRNA	Protein	Name
NM_001168521.1	NP_001161993.1	NAD(+) hydrolase SARM1 isoform 1
NM_172795.3	NP_766383.2	NAD(+) hydrolase SARM1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+ nucleosidase activity	IDA IDA: Inferred from direct assay	28334607	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17724133	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in NAD catabolic process	IDA IDA: Inferred from direct assay	28334607	MGI
involved in NAD catabolic process	IMP IMP: Inferred from mutant phenotype	27735788	MGI
involved in nervous system process	IMP IMP: Inferred from mutant phenotype	17724133	MGI
involved in protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	17724133	MGI
involved in regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21555464	MGI
acts upstream of or within regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17724133	MGI
involved in regulation of synapse pruning	IDA IDA: Inferred from direct assay	22678360	MGI
involved in regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	22678360	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	17724133	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cell surface	IDA IDA: Inferred from direct assay	17804407	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17724133	MGI
located in dendrite	IMP IMP: Inferred from mutant phenotype	21555464	MGI
located in microtubule	IDA IDA: Inferred from direct assay	17724133	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	17724133	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	17724133	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	17724133	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	22678360	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	22678360	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17804407	MGI
located in synapse	IDA IDA: Inferred from direct assay	21555464	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
NAD(+) hydrolase SARM1	NADP(+) hydrolase SARM1 NADase SARM1 Tir-1 homolog sterile alpha and TIR motif containing 1 sterile alpha and TIR motif-containing protein 1

Sarm1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Sarm1	Q6PDS3	GHITM	Homo sapiens	Q9H3K2	Anti Tag CoIP	21903422
Cross	Sarm1	Q6PDS3	NLRX1	Homo sapiens	Q86UT6	Anti Tag CoIP	21903422
Cross	Sarm1	Q6PDS3	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	21903422
Cross	Sarm1	Q6PDS3	STT3A	Homo sapiens	P46977	Anti Tag CoIP	21903422
Cross	Sarm1	Q6PDS3	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.55%	Unkown
HY-B0985A	Phenazopyridine	Antagonist	99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-129522	Sulfo-ara-F-NMN	Activator	99.36%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W021879	DSRM-3716	Inhibitor	99.91%	Unkown
HY-145917	SARM1-IN-2	Inhibitor	99.97%	Unkown
HY-128700	Nicotinic acid mononucleotide	Activator	98.08%	Unkown
HY-Z0816	Dehydronitrosonisoldipine	Antagonist	98.86%	Unkown
HY-178159	SA91-0178	Inhibitor	98.14%	Unkown
HY-128700A	Nicotinic acid mononucleotide triethylamine	Activator	99.89%	Unkown
HY-171213	NB-3	Inhibitor	99.89%	Unkown
HY-173276	SARM1-IN-4	Inhibitor	/	Unkown
HY-203012	NB-7	Inhibitor	99.82%	Unkown
HY-182500	SARM1-IN-9		98.42%	Unkown
HY-161918	SARM1-IN-3	Inhibitor	/	Unkown
HY-172967	SARM1-IN-5	Inhibitor	99.93%	Unkown
HY-172967A	(R)-SARM1-IN-5	Control	97.68%	Unkown
HY-176487	SARM1-IN-6		/	Unkown
HY-182500A	(S,S)-SARM1-IN-9	Inhibitor	99.67%	Unkown
HY-RS12446	SARM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175496	Acid Ceramidase-IN-3	Inhibitor	/	Unkown
HY-176783	GNE-5152	Inhibitor	/	Unkown
HY-179598	SARM1-IN-8	Inhibitor	/	Unkown
HY-182940	SARM1-IN-10	Inhibitor	/	Unkown
HY-RS16722	Sarm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23158	Sarm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W008341	5-Chloroisoquinoline	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sarm1	NCBI	NCBI:23098