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Cat. No.: HY-190991

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SARM1-IN-11

SARM1-IN-11 is a SARM1 inhibitor with an IC₅₀ of 30 nM. SARM1-IN-11 inhibits SARM1 enzyme activity by targeting the TIR domain NADase involved in axonal degeneration.

For research use only. We do not sell to patients.

Formula: C₁₉H₁₅ClN₆O
Molecular Weight:378.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

SARM1-IN-11 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SARM1-IN-11 is a SARM1 inhibitor with an IC₅₀ of 30 nM. SARM1-IN-11 inhibits SARM1 enzyme activity by targeting the TIR domain NADase involved in axonal degeneration^[1]^[2].

IC₅₀ & Target

^[1]^[2]

SARM1

30 nM (IC₅₀)

In Vitro

SARM1-IN-11 (compound 73) inhibits SARM1 in a cell-free enzymatic assay with an IC₅₀ of 30 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 378.82
Formula C₁₉H₁₅ClN₆O
SMILES

N#CC1C(C2=CC=C(C=C2)Cl)CN(C1)C(C3=NNC(C4=CN=NC=C4)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rong J, et al. Novel Substituted Pyrazoles as SARM1 Inhibitors. ACS Med Chem Lett. [Patent Highlight].

[2]. Aregger N, et al; F. Hoffmann-La Roche AG, assignee. WO2025/045746 A1 [PCT patent]. 2025 Mar 6.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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