GHITM - growth hormone inducible transmembrane protein Gene

Also Known as DERP2; MICS1; My021; PTD010; TMBIM5; HSPC282

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27069

About GHITM

Cytogenetic location: 10q23.1 Genomic coordinates (GRCh38): 10:84,139,509-84,153,568 (from NCBI)

This gene has 13 transcripts (splice variants), 230 orthologues and 5 paralogues. Ubiquitous expression in heart (RPKM 139.5), kidney (RPKM 133.1) and 25 other tissues.

Summary

Involved in inner mitochondrial membrane organization and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

GHITM Products (1)

mRNA Protein Name
NM_014394.3 NP_055209.2 growth hormone-inducible transmembrane protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
36321428 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium export from the mitochondrion IMP
IMP: Inferred from mutant phenotype
35912435 GOA
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
36321428 GOA
involved in inner mitochondrial membrane organization IMP
IMP: Inferred from mutant phenotype
18417609 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
35912435 GOA
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
18417609 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
18417609 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GHITM Protein Structure

BaxI_1

BaxI_1: Bax inhibitor 1 like (5 - 89)

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (122 - 336)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

growth hormone-inducible transmembrane protein

  • dermal papilla-derived protein 2

GHITM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GHITM Q9H3K2 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
GHITM Q9H3K2 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
GHITM Q9H3K2 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
GHITM Q9H3K2 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra
GHITM Q9H3K2 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra
GHITM Q9H3K2 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra
GHITM Q9H3K2 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
GHITM Q9H3K2 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
GHITM Q9H3K2 JSRP1 Homo sapiens Q96MG2
Y2H Prey Pooling
32296183
Intra
GHITM Q9H3K2 JSRP1 Homo sapiens Q96MG2
Y2H Array
32296183
Intra
GHITM Q9H3K2 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
GHITM Q9H3K2 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
GHITM Q9H3K2 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
GHITM Q9H3K2 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Cross
GHITM Q9H3K2 orf9c_sars2 SARS-CoV-2 P0DTD3
Y2H Array
36217030
Intra
GHITM Q9H3K2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
GHITM Q9H3K2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
GHITM Q9H3K2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Persistent Moderate Asthma
Persistent Mild Asthma
Inflammatory Bowel Disease 20

  • IBD20
Celery Allergy
Pollen Allergy

  • Hay Fever
Vegetable Allergy
Shrimp Allergy
Crustacean Allergy
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Respiratory Allergy

  • Airway Allergy
Thunderstorm Triggered Asthma

  • Thunderstorm Asthma

  • Thunderstorm Related Asthma
Nose Disease

  • Nose Diseases

  • Disorder Of The Nose

  • Nasal Disorder

  • Abnormality Of The Nose
Apple Allergy

  • Malus Domestica Fruit Allergy
Wheat Allergy

  • Wheat Allergic Reaction

  • Wheat Hypersensitivity

  • Allergy To Wheat

  • Allergy Wheat
Chronic Rhinitis

  • Rhinitis - Chronic

  • Chronic Rhinitis Nos

  • Rhinitis

  • Rhinitis Nos
Latex Allergy
Fruit Allergy

  • Allergy To Fruit
Legume Allergy

  • Fabaceae Allergy
Chronic Asthma
Peanut Allergy

  • Allergy To Peanuts

  • Peanut Allergic Reaction

  • Allergies Peanut

  • Peanut Hypersensitivity
Egg Allergy

  • Allergy To Eggs

  • Allergies Egg

  • Egg Hypersensitivity
Occupational Asthma
Environmental Induced Asthma

  • Irritant Asthma
Bronchial Disease

  • Bronchial Diseases

  • Bronchial Disorders

  • Bronchial Spasm
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05411 GHITM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22524 Ghitm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29045 Ghitm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GHITM VGNC VGNC:41205
Macaca mulatta GHITM VGNC VGNC:72735
Bos taurus GHITM VGNC VGNC:29348
Rattus norvegicus GHITM RGD RGD:1359301
Mus musculus GHITM MGD MGI:1913342
Felis catus GHITM VGNC VGNC:62543
Others GHITM NCBI