2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. SARM1-IN-5

SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).

For research use only. We do not sell to patients.

SARM1-IN-5

SARM1-IN-5 Chemical Structure

CAS No. : 2762081-30-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of SARM1-IN-5:

SARM1-IN-5 Related Antibodies

Top Publications Citing Use of Products

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Description

SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS)[1].

Molecular Weight

352.37

Formula

C18H17FN6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@@H](CCCN1C2=NN=C(N2)C3=CC=NC=C3)CC4=CC=C(N=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (283.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8379 mL 14.1896 mL 28.3793 mL
5 mM 0.5676 mL 2.8379 mL 5.6759 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8379 mL 14.1896 mL 28.3793 mL 70.9482 mL
5 mM 0.5676 mL 2.8379 mL 5.6759 mL 14.1896 mL
10 mM 0.2838 mL 1.4190 mL 2.8379 mL 7.0948 mL
15 mM 0.1892 mL 0.9460 mL 1.8920 mL 4.7299 mL
20 mM 0.1419 mL 0.7095 mL 1.4190 mL 3.5474 mL
25 mM 0.1135 mL 0.5676 mL 1.1352 mL 2.8379 mL
30 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3649 mL
40 mM 0.0709 mL 0.3547 mL 0.7095 mL 1.7737 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4190 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8869 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL
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SARM1-IN-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARM1-IN-52762081-30-9Toll-like Receptor (TLR)Toll-like ReceptorTLRAxonal degenerationAlzheimer’s diseaseParkinson’s diseaseamyotrophic lateral sclerosisInhibitorinhibitorinhibit

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