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Cat. No.: HY-176487

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SARM1-IN-6

SARM1-IN-6 (Compound 22b) is a brain-permeable SARM1 orthosteric inhibitor, the IC₅₀ of SARM1-IN-6 against NAM is 0.069 μM.

For research use only. We do not sell to patients.

CAS No.: 3080315-51-8
Formula: C₂₀H₁₉F₂N₃O
Molecular Weight:355.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SARM1-IN-6 Chemical Structure

CAS No.: 3080315-51-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SARM1-IN-6 (Compound 22b) is a brain-permeable SARM1 orthosteric inhibitor, the IC₅₀ of SARM1-IN-6 against NAM is 0.069 μM^[1].

All Toll-like Receptor (TLR) Isoforms :

Chemical Information

CAS No. 3080315-51-8
Molecular Weight 355.38
Formula C₂₀H₁₉F₂N₃O
SMILES

O=C1N(CC[C@H](C2=CN=C(F)C(F)=C2)C1)C34CC(C4)(C5=CC=NC=C5)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Samantha A. Green, et al. Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation. ACS. Vol 16/Issue 6. May 20, 2025.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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SARM1-IN-6

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SARM1-IN-6 Related Classifications

HY-176487 Related Classifications