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Cat. No.: HY-176487

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SARM1-IN-6

SARM1-IN-6 (Compound 22b) is a brain-permeable SARM1 orthosteric inhibitor, the IC₅₀ of SARM1-IN-6 against NAM is 0.069 μM.

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CAS No.: 3080315-51-8
Formule: C₂₀H₁₉F₂N₃O
Masse moléculaire:355.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SARM1-IN-6 Chemical Structure

CAS No.: 3080315-51-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

SARM1-IN-6 (Compound 22b) is a brain-permeable SARM1 orthosteric inhibitor, the IC₅₀ of SARM1-IN-6 against NAM is 0.069 μM^[1].

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Chemical Information

CAS No. 3080315-51-8
Masse moléculaire 355.38
Formule C₂₀H₁₉F₂N₃O
SMILES

O=C1N(CC[C@H](C2=CN=C(F)C(F)=C2)C1)C34CC(C4)(C5=CC=NC=C5)C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Samantha A. Green, et al. Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation. ACS. Vol 16/Issue 6. May 20, 2025.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SARM1-IN-6

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SARM1-IN-6 Related Classifications

HY-176487 Related Classifications