POLDIP2 - DNA polymerase delta interacting protein 2 Gene

Also Known as p38; POLD4; PDIP38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26073

About POLDIP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,346,633-28,357,527 (from NCBI)

This gene has 2 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 32.9), adrenal (RPKM 29.4) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the DNA Polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

POLDIP2 Products (2)

mRNA Protein Name
NM_001290145.2 NP_001277074.1 polymerase delta-interacting protein 2 isoform 2
NM_015584.5 NP_056399.1 polymerase delta-interacting protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16428295 GOA
Biological Process GO Annotation Evidence References Source
involved in error-free translesion synthesis IDA
IDA: Inferred from direct assay
24191025 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
16428295 GOA
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
18063578 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16428295 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLDIP2 Protein Structure

DUF525

DUF525: ApaG domain (253 - 337)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

polymerase delta-interacting protein 2

  • 38 kDa DNA polymerase delta interaction protein

POLDIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLDIP2 Q9Y2S7 DNAAF6 Homo sapiens Q9NQM4
Y2H Prey Pooling
32296183
Intra
POLDIP2 Q9Y2S7 DNAAF6 Homo sapiens Q9NQM4
Y2H Array
32296183
Intra
POLDIP2 Q9Y2S7 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
POLDIP2 Q9Y2S7 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
POLDIP2 Q9Y2S7 CHCHD2 Homo sapiens Q9Y6H1
Validated Y2H
32296183
Intra
POLDIP2 Q9Y2S7 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra
POLDIP2 Q9Y2S7 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

POLDIP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81935 POLDIP2 Antibody (YA1680) WB, FC, IP Human, Mouse, Rat
HY-P81935A POLDIP2 Antibody (YA1680)(PBS only) WB, FC, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10823 POLDIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLDIP2 VGNC VGNC:99322
Bos taurus POLDIP2 VGNC VGNC:33116
Rattus norvegicus POLDIP2 RGD RGD:1307022
Macaca mulatta POLDIP2 VGNC VGNC:76099
Canis familiaris POLDIP2 VGNC VGNC:44777
Mus musculus POLDIP2 MGD MGI:1915061
Others POLDIP2 NCBI