CCAR1 - cell division cycle and apoptosis regulator 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55749

About CCAR1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,721,239-68,792,377 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 17.5), appendix (RPKM 15.2) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]

CCAR1 Products (3)

mRNA Protein Name
NM_001282959.2 NP_001269888.1 cell division cycle and apoptosis regulator protein 1 isoform b
NM_001282960.2 NP_001269889.1 cell division cycle and apoptosis regulator protein 1 isoform b
NM_018237.4 NP_060707.2 cell division cycle and apoptosis regulator protein 1 isoform a

CCAR1 Protein Structure

S1-like

S1-like: S1-like (147 - 204)

DBC1

DBC1: DBC1 (478 - 608)

SAP

SAP: SAP domain (637 - 669)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1150 a.a.
Protein Preferred Names Protein Names

cell division cycle and apoptosis regulator protein 1

  • cell cycle and apoptosis regulatory protein 1

CCAR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCAR1 Q8IX12 DNAAF6 Homo sapiens Q9NQM4
Y2H Prey Pooling
25416956
Intra
CCAR1 Q8IX12 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CCAR1 Q8IX12 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CCAR1 Q8IX12 TRIM63 Homo sapiens Q969Q1
Y2H
18157088
Intra
CCAR1 Q8IX12 TRIM63 Homo sapiens Q969Q1
Pull Down
18157088
Intra
CCAR1 Q8IX12 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
CCAR1 Q8IX12 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
CCAR1 Q8IX12 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CCAR1 Q8IX12 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CCAR1 Q8IX12 WWTR1 Homo sapiens Q9GZV5
Anti Bait CoIP
20594350
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Drug-Induced Lupus Erythematosus

  • Dile

  • Dil

  • Drug-Induced Systemic Lupus Erythematosus
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119331 CFM-5 Inducer 99.48% Unkown
HY-RS02020 CCAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22417 Ccar1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28940 Ccar1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CCAR1 RGD RGD:1560358
Mus musculus CCAR1 MGD MGI:1914750
Felis catus CCAR1 VGNC VGNC:60442
Bos taurus CCAR1 VGNC VGNC:106671
Macaca mulatta CCAR1 VGNC VGNC:97743
Canis familiaris CCAR1 VGNC VGNC:38773
Others CCAR1 NCBI