P2RX4 - purinergic receptor P2X 4 Gene

Also Known as P2X4; P2X4R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5025

About P2RX4

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,210,129-121,234,106 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2RX4 Products (11)

mRNA Protein Name
NM_001261397.2 NP_001248326.1 P2X purinoceptor 4 isoform 3
XM_047428911.1 XP_047284867.1 P2X purinoceptor 4 isoform X3
NR_046372.2
XM_011538416.3 XP_011536718.1 P2X purinoceptor 4 isoform X2
XM_047428910.1 XP_047284866.1 P2X purinoceptor 4 isoform X1
NM_001261398.2 NP_001248327.1 P2X purinoceptor 4 isoform 4
NR_046373.2
NM_175568.1
NM_175567.1
NM_001256796.2 NP_001243725.1 P2X purinoceptor 4 isoform 1
NM_002560.3 NP_002551.2 P2X purinoceptor 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding IPI
IPI: Inferred from physical interaction
12088286 GOA
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
9016352 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
9016352 GOA
enables ligand-gated calcium channel activity IDA
IDA: Inferred from direct assay
9016352 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
9016352 GOA
enables purinergic nucleotide receptor activity IMP
IMP: Inferred from mutant phenotype
11606481 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17264311 GOA
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
9016352 GOA
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
10515189 GOA
involved in membrane depolarization IDA
IDA: Inferred from direct assay
9016352 GOA
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
10515189 GOA
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
15130891 GOA
involved in positive regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
21106936 GOA
involved in positive regulation of calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
10969036 GOA
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: Inferred from mutant phenotype
10899068 GOA
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
10969036 GOA
involved in positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
10899068 GOA
involved in positive regulation of endothelial cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21106936 GOA
involved in purinergic nucleotide receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11606481 GOA
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11606481 GOA
involved in regulation of cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
11606481 GOA
involved in relaxation of cardiac muscle IMP
IMP: Inferred from mutant phenotype
11606481 GOA
involved in response to ATP IDA
IDA: Inferred from direct assay
9016352 GOA
involved in response to fluid shear stress IDA
IDA: Inferred from direct assay
10969036 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
9016352 GOA
Cellular Component GO Annotation Evidence References Source
located in cell junction IDA
IDA: Inferred from direct assay
12088286 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
9016352 GOA
located in membrane IDA
IDA: Inferred from direct assay
17785580 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12088286 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23303206 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
10515189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX4 Protein Structure

P2X_receptor

P2X_receptor: ATP P2X receptor (13 - 385)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 4

  • ATP receptor

  • ATP-gated cation channel protein

  • P2X receptor, subunit 4

  • purinergic receptor P2X, ligand gated ion channel, 4

  • purinergic receptor P2X4

  • purinoceptor P2X4

P2RX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2RX4 Q99571 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
P2RX4 Q99571 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
P2RX4 Q99571 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
P2RX4 Q99571 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
P2RX4 Q99571 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
P2RX4 Q99571 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
P2RX4 Q99571 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
P2RX4 Q99571 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Paine Syndrome

  • Pain Disorder

  • Pain

  • Microcephaly With Spastic Diplegia

  • Pain Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus P2RX4 VGNC VGNC:68671
Canis familiaris P2RX4 VGNC VGNC:44210
Mus musculus P2RX4 MGD MGI:1338859
Macaca mulatta P2RX4 VGNC VGNC:75734
Rattus norvegicus P2RX4 RGD RGD:62073
Bos taurus P2RX4 VGNC VGNC:32520
Others P2RX4 NCBI