EPC1 - enhancer of polycomb homolog 1 Gene

Homo sapiens

Also known as Epl1

Gene ID: 80314 | Gene type: protein coding

About EPC1

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,267,751-32,378,769 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.1), ovary (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 Histone Acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to Apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

EPC1 Products(8)

mRNA	Protein	Name
NM_001272004.3	NP_001258933.1	enhancer of polycomb homolog 1 isoform b
NM_001272019.4	NP_001258948.1	enhancer of polycomb homolog 1 isoform c
NM_001282391.3	NP_001269320.1	enhancer of polycomb homolog 1 isoform d
NM_001382753.1	NP_001369682.1	enhancer of polycomb homolog 1 isoform e
NM_001382754.1	NP_001369683.1	enhancer of polycomb homolog 1 isoform f
NM_001382755.1	NP_001369684.1	enhancer of polycomb homolog 1 isoform g
NM_001382756.1	NP_001369685.1	enhancer of polycomb homolog 1 isoform h
NM_025209.5	NP_079485.1	enhancer of polycomb homolog 1 isoform a

EPC1 Protein Structure

EPL1

E_Pc_C

0
200
400
600
836 a.a.

Protein Preferred Names

Protein Names

enhancer of polycomb homolog 1

Related Diseases

Diseases

Alias

Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia	Atll
Adult T-Cell Leukaemia	Adult T-Cell Leukaemia/Lymphoma
Adult T-Cell Lymphoma	T Cell Leukemia Lymphoma Adult
Leukemia-Lymphoma, Adult T-Cell	Leukemia, T-Cell
Adult T-Cell Lymphoma/Leukemia

Apolipoprotein C-Iii Deficiency

Hyperalphalipoproteinemia 2

HALP2

Noonan Syndrome 11

NS11

Noonan Syndrome 8

NS8	Noonan Syndrome, Type 8

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04418	EPC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EPC1	MGD	MGI:1278322
Bos taurus	EPC1	VGNC	VGNC:28527
Macaca mulatta	EPC1	VGNC	VGNC:72074
Felis catus	EPC1	VGNC	VGNC:61898
Canis familiaris	EPC1	VGNC	VGNC:40400
Rattus norvegicus	EPC1	RGD	RGD:2324280