SFR1 - SWI5 dependent homologous recombination repair protein 1 Gene

Also Known as MEI5; MEIR5; C10orf78; bA373N18.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 119392

About SFR1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,120,166-104,126,383 (from NCBI)

This gene has 3 transcripts (splice variants) and 190 orthologues. Broad expression in testis (RPKM 6.8), appendix (RPKM 2.8) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

SFR1 Products (4)

mRNA Protein Name
NM_001002759.2 NP_001002759.1 swi5-dependent recombination DNA repair protein 1 homolog isoform a
NM_001384829.1 NP_001371758.1 swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_001384830.1 NP_001371759.1 swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_145247.5 NP_660290.3 swi5-dependent recombination DNA repair protein 1 homolog isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
23874500 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21252223 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
23874500 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
21252223 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23874500 GOA
Cellular Component GO Annotation Evidence References Source
part of Swi5-Sfr1 complex IDA
IDA: Inferred from direct assay
21252223 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23874500 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFR1 Protein Structure

Mei5

Mei5: Double-strand recombination repair protein (25 - 236)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

swi5-dependent recombination DNA repair protein 1 homolog

  • MEI5 recombination repair protein homolog

SFR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SFR1 Q86XK3 HMBOX1 Homo sapiens Q6NT76-2
Validated Y2H
25416956
Intra
SFR1 Q86XK3 HMBOX1 Homo sapiens Q6NT76-2
Y2H Array
25416956
Intra
SFR1 Q86XK3 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
SFR1 Q86XK3 SWI5 Homo sapiens Q1ZZU3
Anti Tag CoIP
33961781
Intra
SFR1 Q86XK3 SWI5 Homo sapiens Q1ZZU3
Anti Tag CoIP
21252223
Intra
SFR1 Q86XK3 SWI5 Homo sapiens Q1ZZU3
Pull Down
21252223
Intra
SFR1 Q86XK3 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra
SFR1 Q86XK3 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra
SFR1 Q86XK3 RINT1 Homo sapiens Q6NUQ1
Y2H Array
31515488
Intra
SFR1 Q86XK3 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
25416956
Intra
SFR1 Q86XK3 RINT1 Homo sapiens Q6NUQ1
Y2H Array
25416956
Intra
SFR1 Q86XK3 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
SFR1 Q86XK3 RNF40 Homo sapiens O75150
Validated Y2H
25416956
Intra
SFR1 Q86XK3 RNF40 Homo sapiens O75150
Y2H Array
25416956
Intra
SFR1 Q86XK3 RNF40 Homo sapiens O75150
Anti Tag CoIP
33961781
Intra
SFR1 Q86XK3 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
SFR1 Q86XK3 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Atrial Septal Defect 4

  • ASD4

  • Atrial Heart Septal Defect 4

  • Septal Defect, Atrial, Type 4
Atrial Septal Defect 3

  • ASD3

  • Atrial Heart Septal Defect 3

  • Septal Defect, Atrial, Type 3
Branchiootorenal Syndrome 2

  • BOR2

  • Bor Syndrome 2

  • Branchiootorenal Dysplasia 2

  • Branchio-Oto-Renal Dysplasia 2

  • Branchio-Oto-Renal Syndrome Type 2

  • Branchiootorenal Syndrome, Type 2
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12771 SFR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SFR1 VGNC VGNC:34519
Macaca mulatta SFR1 VGNC VGNC:106099
Mus musculus SFR1 MGD MGI:1915038
Rattus norvegicus SFR1 RGD RGD:1305481
Canis familiaris SFR1 VGNC VGNC:46079
Felis catus SFR1 VGNC VGNC:65063
Others SFR1 NCBI