SWI5 - SWI5 homologous recombination repair protein Gene

Also Known as SAE3; C9orf119

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375757

About SWI5

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,275,356-128,288,989 (from NCBI)

This gene has 7 transcripts (splice variants) and 178 orthologues. Broad expression in testis (RPKM 16.4), thyroid (RPKM 8.7) and 25 other tissues.

Summary

Involved in cellular response to ionizing radiation and double-strand break repair via homologous recombination. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

SWI5 Products (4)

mRNA Protein Name
NM_001040011.2 NP_001035100.2 DNA repair protein SWI5 homolog isoform 1
NM_001318089.2 NP_001305018.2 DNA repair protein SWI5 homolog isoform 2
NM_001318092.2 NP_001305021.1 DNA repair protein SWI5 homolog isoform 3
NM_001379267.1 NP_001366196.1 DNA repair protein SWI5 homolog isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21252223 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
23754376 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
21252223 GOA
Cellular Component GO Annotation Evidence References Source
part of Swi5-Sfr1 complex IDA
IDA: Inferred from direct assay
21252223 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SWI5 Protein Structure

Swi5

Swi5: Swi5 (156 - 235)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

DNA repair protein SWI5 homolog

  • HBV DNAPTP1-transactivated protein A

SWI5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SWI5 Q1ZZU3 SFR1 Homo sapiens Q86XK3
Pull Down
21252223
Intra
SWI5 Q1ZZU3 SFR1 Homo sapiens Q86XK3
Anti Tag CoIP
21252223
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hordeolum

  • Stye

  • Boil Of Eyelid

  • Furuncle Of Eyelid

  • Hordeolum Externum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14064 SWI5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21439 Swi5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27957 Swi5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SWI5 RGD RGD:1559966
Mus musculus SWI5 MGD MGI:1920181
Felis catus SWI5 VGNC VGNC:102993
Canis familiaris SWI5 VGNC VGNC:106612
Others SWI5 NCBI