SNX11 - sorting nexin 11 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29916

About SNX11

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,107,523-48,123,601 (from NCBI)

This gene has 13 transcripts (splice variants), 206 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), spleen (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

SNX11 Products (3)

mRNA Protein Name
NM_001330320.2 NP_001317249.1 sorting nexin-11 isoform 2
NM_013323.3 NP_037455.2 sorting nexin-11 isoform 1
NM_152244.2 NP_689450.1 sorting nexin-11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol phosphate binding IDA
IDA: Inferred from direct assay
23615901 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in vesicle organization IMP
IMP: Inferred from mutant phenotype
23615901 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26818531 GOA
located in endosome IDA
IDA: Inferred from direct assay
23615901 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26818531 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX11 Protein Structure

PX

PX: PX domain (15 - 128)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

sorting nexin-11

SNX11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNX11 Q9Y5W9 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra
SNX11 Q9Y5W9 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 SMYD2 Homo sapiens Q9NRG4
Y2H Array
32296183
Intra
SNX11 Q9Y5W9 SMYD2 Homo sapiens Q9NRG4
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra
SNX11 Q9Y5W9 MAJIN Homo sapiens Q3KP22-3
Y2H Array
32296183
Intra
SNX11 Q9Y5W9 MAJIN Homo sapiens Q3KP22-3
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
SNX11 Q9Y5W9 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Array
25416956
Intra
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
25416956
Intra
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Validated Y2H
25416956
Intra
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
25416956
Intra
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Penis Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Penis

  • Epidermoid Cell Carcinoma Of Penis

  • Squamous Cell Carcinoma Of The Penis

  • Penile Squamous Cell Carcinoma
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency

  • Pnpo Deficiency

  • Pyridoxamine 5'-Phosphate Oxidase Deficiency

  • Pnpo-Related Neonatal Epileptic Encephalopathy

  • Pyridoxal Phosphate-Responsive Seizures

  • Pyridoxal 5'-Phosphate-Dependent Epilepsy

  • Pyridoxine-5'-Phosphate Oxidase Deficiency

  • PNPOD

  • Seizures, Pyridoxine-Resistant, Plp-Sensitive

  • Pyridoxal Phosphate-Dependent Seizures

  • Pyridoxamine 5'-Oxidase Deficiency

  • Epileptic Encephalopathy, Neonatal, Pnpo-Related

  • Pyridox Ine 5'-Phosphate Oxidase Deficiency

  • Deficiency, Pyridoxamine 5'-Phosphate Oxidase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13524 SNX11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SNX11 VGNC VGNC:35092
Rattus norvegicus SNX11 RGD RGD:1307319
Mus musculus SNX11 MGD MGI:1921729
Macaca mulatta SNX11 VGNC VGNC:77706
Felis catus SNX11 VGNC VGNC:65542
Canis familiaris SNX11 VGNC VGNC:46621
Others SNX11 NCBI