TGM7 - transglutaminase 7 Gene

Also Known as TGMZ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116179

About TGM7

Cytogenetic location: 15q15.2-q15.3 Genomic coordinates (GRCh38): 15:43,276,271-43,302,255 (from NCBI)

This gene has 2 transcripts (splice variants), 121 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related Enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002]

TGM7 Products (1)

mRNA Protein Name
NM_052955.3 NP_443187.1 protein-glutamine gamma-glutamyltransferase Z

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM7 Protein Structure

Transglut_N

Transglut_N: Transglutaminase family (7 - 124)

Transglut_core

Transglut_core: Transglutaminase-like superfamily (275 - 362)

Transglut_C

Transglut_C: Transglutaminase family, C-terminal ig like domain (608 - 705)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
Protein Preferred Names Protein Names

protein-glutamine gamma-glutamyltransferase Z

  • TG(Z)

TGM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TGM7 Q96PF1 LAMTOR3 Homo sapiens Q9UHA4
Validated Y2H
32296183
Intra
TGM7 Q96PF1 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Validated Y2H
32296183
Intra
TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32296183
Intra
TGM7 Q96PF1 UNKL Homo sapiens Q9H9P5-5
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
TGM7 Q96PF1 SDS Homo sapiens P20132
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 SDS Homo sapiens P20132
Y2H Array
32296183
Intra
TGM7 Q96PF1 SPRY1 Homo sapiens O43609
Y2H Array
32296183
Intra
TGM7 Q96PF1 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
TGM7 Q96PF1 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
Intra
TGM7 Q96PF1 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
TGM7 Q96PF1 KCTD1 Homo sapiens Q719H9
Y2H Array
32296183
Intra
TGM7 Q96PF1 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
32296183
Intra
TGM7 Q96PF1 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra
TGM7 Q96PF1 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinal Lattice Degeneration

  • Palisade Degeneration Of Retina

  • Lattice Retinal Degeneration
Richter'S Syndrome

  • Richter Syndrome

  • Richter Transformation
Gingival Fibromatosis

  • Hereditary Gingival Fibromatosis

  • Hereditary Gingival Hyperplasia

  • Autosomal Dominant Gingival Fibromatosis

  • Autosomal Dominant Gingival Hyperplasia

  • Fibromatosis, Gingival, Hereditary

  • Fibromatosis, Gingival
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14464 TGM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TGM7 RGD RGD:7615199
Canis familiaris TGM7 VGNC VGNC:47320
Felis catus TGM7 VGNC VGNC:66145
Mus musculus TGM7 MGD MGI:2151164
Bos taurus TGM7 VGNC VGNC:35814
Macaca mulatta TGM7 VGNC VGNC:79880
Others TGM7 NCBI