SDS - serine dehydratase Gene

Homo sapiens

Also known as SDH

Gene ID: 10993 | Gene type: protein coding

About SDS

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,392,445-113,403,887 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 5 paralogues. Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0).

Summary

This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]

SDS Products(1)

mRNA	Protein	Name
NM_006843.3	NP_006834.2	L-serine dehydratase/L-threonine deaminase

SDS Protein Structure

PALP

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

L-serine dehydratase/L-threonine deaminase

L-serine ammonia-lyase

Related Diseases

Diseases

Alias

Breast Abscess

Abscess Of Breast

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0014	Brilliant blue G-250		≥95.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Purity	Rare Diseases
HY-108717	Proteinase K	/	Unkown
HY-W099535	Lithium dodecyl sulfate	≥98.0%	Unkown
HY-D0232	Brilliant Blue R250	≥95.0%	Unkown
HY-136964	Sulfo-NHS-Biotin sodium	94.50%	Unkown
HY-D1590	BODIPY Green 8-P2M	99.21%	Unkown
HY-119271	CMLD010509	/	Unkown
HY-Y0700	Calconcarboxylic acid	/	Unkown
HY-RS12599	SDS Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SDS	VGNC	VGNC:80482
Rattus norvegicus	SDS	RGD	RGD:67376
Bos taurus	SDS	VGNC	VGNC:34399
Mus musculus	SDS	MGD	MGI:98270
Macaca mulatta	SDS	VGNC	VGNC:77148

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