ZD 9379 sodium
ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc.
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- CAS No.: 170142-29-7
- Formule: C19H15ClN3NaO4
- Masse moléculaire:406.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCAO model established in male Sprague-Dawley rats (weighing 290-340 grams)[1]
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Dosage:5 mg/kg
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Administration:Intravenous injection (i.v.), for 4 hours
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Result:Significantly reduced infarction volume, and the number of SDs was significantly decreased.
Significantly improved neurological scores, without causing significant changes in physiological parameters or behavioral side effects.
Chemical Information
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CAS No. 170142-29-7
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Masse moléculaire 406.77
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Formule C19H15ClN3NaO4
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SMILES
O=C1C2=C(C(NN1C3=C(C=C(OC)C=C3)C)=O)NC4=C(C=CC(Cl)=C4)C2=O.[Na]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Tatlisumak T, et al. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir Suppl. 2000;76:331-3. [Content Brief]
[2]. Catarzi D, Colotta V, Varano F. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZD 9379 sodium Related Classifications
HY-106969A Related Classifications
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