Sodium hexadecyl sulfate
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Sodium hexadecyl sulfate is a long-chain anionic surfactant. Sodium hexadecyl sulfate can act as an interface-regulating substance to form a soft layer on the surface of carbon nanotubes, guide proteins to adsorb in the correct orientation with active sites facing outward through electrostatic interactions, and significantly enhance the activity of immobilized enzymes. Sodium hexadecyl sulfate can replace or supplement SDS (HY-Y0316) in capillary gel electrophoresis (CGE).
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 1120-01-0
- Formula: C16H33NaO4S
- Molecular Weight:344.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sodium hexadecyl sulfate assembles into a soft layered structure on the surface of carbon nanotubes, and rearranges into a saddle-like structure upon interaction with lysozyme. It maintains the accessibility of lysozyme's active site by adjusting the orientation of lysozyme, while functionalizing carbon nanotubes to improve their water dispersibility and promote lysozyme adsorption[1].
Sodium hexadecyl sulfate eliminates the dependence of aggregate quantification on protein loading amount, aligns the detection level with the results of size-exclusion chromatography, thereby reducing method-induced false-positive artifacts of aggregates in non-reducing capillary gel electrophoresis, and also enhances the denaturation of therapeutic proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1120-01-0
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Appearance Solid
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Molecular Weight 344.49
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Formula C16H33NaO4S
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCOS(=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (145.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (760 KB)
- English - EN (760 KB)
- Français - FR (760 KB)
- Deutsch - DE (760 KB)
- Norwegian - NO (760 KB)
- Español - ES (760 KB)
- Swedish - SV (760 KB)
- Italian - IT (760 KB)
- Portuguese - PT (760 KB)
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Handling Instructions (2659 KB)
References
[1]. Sun J, et al. Sodium hexadecyl sulfate as an interfacial substance adjusting the adsorption of a protein on carbon nanotubes. ACS Appl Mater Interfaces. 2014;6(17):15132-15139. [Content Brief]
[2]. Guan Q, et al. Enhancement of covalent aggregate quantification of protein therapeutics by non-reducing capillary gel electrophoresis using sodium hexadecyl sulfate (CE-SHS). J Chromatogr B Analyt Technol Biomed Life Sci. 2020;1152:122230. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9028 mL | 14.5142 mL | 29.0284 mL | 72.5710 mL |
| 5 mM | 0.5806 mL | 2.9028 mL | 5.8057 mL | 14.5142 mL | |
| 10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL | 7.2571 mL | |
| 15 mM | 0.1935 mL | 0.9676 mL | 1.9352 mL | 4.8381 mL | |
| 20 mM | 0.1451 mL | 0.7257 mL | 1.4514 mL | 3.6286 mL | |
| 25 mM | 0.1161 mL | 0.5806 mL | 1.1611 mL | 2.9028 mL | |
| 30 mM | 0.0968 mL | 0.4838 mL | 0.9676 mL | 2.4190 mL | |
| 40 mM | 0.0726 mL | 0.3629 mL | 0.7257 mL | 1.8143 mL | |
| 50 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4514 mL | |
| 60 mM | 0.0484 mL | 0.2419 mL | 0.4838 mL | 1.2095 mL | |
| 80 mM | 0.0363 mL | 0.1814 mL | 0.3629 mL | 0.9071 mL | |
| 100 mM | 0.0290 mL | 0.1451 mL | 0.2903 mL | 0.7257 mL |
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