SNRPB - small nuclear ribonucleoprotein polypeptides B and B1 Gene

Also Known as COD; CCMS; SNRPB1; SmB/B'; Sm-B/B'; snRNP-B; SmB/SmB'

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6628

About SNRPB

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,461,642-2,470,789 (from NCBI)

This gene has 10 transcripts (splice variants), 228 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 101.8), lymph node (RPKM 67.1) and 25 other tissues.

Summary

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]

SNRPB Products (2)

mRNA	Protein	Name
NM_003091.4	NP_003082.1	small nuclear ribonucleoprotein-associated proteins B and B' isoform B
NM_198216.2	NP_937859.1	small nuclear ribonucleoprotein-associated proteins B and B' isoform B'

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8076607	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
acts upstream of or within protein methylation	IDA IDA: Inferred from direct assay	18495660	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPB Protein Structure

LSM

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
small nuclear ribonucleoprotein-associated proteins B and B'	B polypeptide of Sm protein

SNRPB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRPB	P14678	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Bait CoIP	37248947
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	X-Ray Diffraction	19325628
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Ion Exchange Chrom	19325628
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Comig Non-Denat Gel	18984161
Intra	SNRPB	P14678	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	STRAP	Homo sapiens	Q9Y3F4	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	STRAP	Homo sapiens	Q9Y3F4	Pull Down	15848170
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Y2H	16000308
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	NMR	16000308
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Y2H Array	31515488
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Peptide Array	15105431
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Confocal	15105431
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	SNRPB	P14678	COIL	Homo sapiens	P38432	Pull Down	21070772
Intra	SNRPB	P14678	COIL	Homo sapiens	P38432	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Rare Disease With Pierre Robin Syndrome
Pierre Robin Syndrome	Pierre Robin Sequence Glossoptosis, Micrognathia, And Cleft Palate Pierre Robin Syndrome Skeletal Dysplasia Polydactyly Pierre-Robin Syndrome Isolated Pierre Robin Sequence Isolated Pierre-Robin Syndrome PRBNS Robin Sequence Robin Syndrome Isolated Pierre Robin Syndrome
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Burn-Mckeown Syndrome	Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome Oculootofacial Dysplasia BMKS Oofd Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome Choanal Atresia Deafness Cardiac Defects Dysmorphism Oculo-Oto-Facial Dysplasia
Mandibulofacial Dysostosis, Guion-Almeida Type	Mandibulofacial Dysostosis With Microcephaly Mandibulofacial Dysostosis-Microcephaly Syndrome MFDGA MFDM Mfdm Syndrome Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome Dysostosis, Mandibulofacial, Guion-Almeida Type
Acrofacial Dysostosis 1, Nager Type	Nager Syndrome Nager Acrofacial Dysostosis AFD1 Preaxial Acrofacial Dysostosis Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies Afd, Nager Type Nager Acrofacial Dysostosis Syndrome Nafd Acrofacial Dysostosis, Nager Type Afd Preaxial Manibulofacial Dysostosis Split Hand Deformity-Mandibulofacial Dysostosis Preaxial Mandibulofacial Dysostosis Mandibulofacial Dysostosis With Preaxial Limb Anomalies Preaxial Acrodysostosis Afd Nager Type Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Microcephaly, Autosomal Dominant	Autosomal Dominant Microcephaly Microcephaly Autosomal Dominant Autosomal Dominant Primary Microcephaly Microcephaly With Autosomal Dominant Inheritance
Acrofacial Dysostosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13502	SNRPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13503	SNRPB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SNRPB	VGNC	VGNC:99671
Macaca mulatta	SNRPB	VGNC	VGNC:77676
Bos taurus	SNRPB	VGNC	VGNC:35076
Rattus norvegicus	SNRPB	RGD	RGD:621301
Mus musculus	SNRPB	MGD	MGI:98342
Others	SNRPB	NCBI