SNRPD3 - small nuclear ribonucleoprotein D3 polypeptide Gene

Also Known as SMD3; Sm-D3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6634

About SNRPD3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,555,650-24,574,971 (from NCBI)

This gene has 3 transcripts (splice variants), 222 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 22.3), prostate (RPKM 19.1) and 25 other tissues.

Summary

This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SNRPD3 Products (2)

mRNA	Protein	Name
NM_001278656.2	NP_001265585.1	small nuclear ribonucleoprotein Sm D3
NM_004175.5	NP_004166.1	small nuclear ribonucleoprotein Sm D3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables U7 snRNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	17709427	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10500148	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
acts upstream of or within protein methylation	IDA IDA: Inferred from direct assay	18495660	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of pICln-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPD3 Protein Structure

LSM

0
100
126 a.a.

Protein Preferred Names	Protein Names
small nuclear ribonucleoprotein Sm D3	small nuclear ribonucleoprotein D3 polypeptide 18kDa

SNRPD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRPD3	P62318	SNRPB2	Homo sapiens	P08579	Crosslink	30021884
Intra	SNRPD3	P62318	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPD3	P62318	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPD3	P62318	LSM3	Homo sapiens	P62310	Y2H	22365833
Intra	SNRPD3	P62318	LSM7	Homo sapiens	Q9UK45	Y2H	21988832
Intra	SNRPD3	P62318	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	SNRPD3	P62318	SNRPB	Homo sapiens	P14678	Y2H	22365833
Intra	SNRPD3	P62318	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SNRPD3	P62318	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	SNRPD3	P62318	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	SNRPD3	P62318	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	SNRPD3	P62318	CLNS1A	Homo sapiens	P54105	Y2H	21988832
Intra	SNRPD3	P62318	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SNRPD3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82281	SNRPD3 Antibody (YA2026)	WB	Human, Rat
HY-P82281A	SNRPD3 Antibody (YA2026)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13507	SNRPD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21198	Snrpd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27714	Snrpd3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRPD3	MGD	MGI:1914582
Rattus norvegicus	SNRPD3	RGD	RGD:1597573
Bos taurus	SNRPD3	VGNC	VGNC:35080
Felis catus	SNRPD3	VGNC	VGNC:80491
Macaca mulatta	SNRPD3	VGNC	VGNC:77678
Others	SNRPD3	NCBI