LSM7 - LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as YNL147W

Gene ID: 51690 | Gene type: protein coding

About LSM7

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,321,521-2,328,586 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 29.6), bone marrow (RPKM 20.9) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM7 Products(1)

mRNA	Protein	Name
NM_016199.3	NP_057283.1	U6 snRNA-associated Sm-like protein LSm7

LSM7 Protein Structure

LSM

0
103 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm7

LSM7 U6 small nuclear RNA and mRNA degradation associated

Related Diseases

Diseases

Alias

Leukodystrophy

Leukodystrophies

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07862	LSM7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LSM7	VGNC	VGNC:42846
Felis catus	LSM7	VGNC	VGNC:63325
Mus musculus	LSM7	MGD	MGI:1913344
Bos taurus	LSM7	VGNC	VGNC:31059
Rattus norvegicus	LSM7	RGD	RGD:1305354