LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as YER146W

Gene ID: 23658 | Gene type: protein coding

About LSM5

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:32,485,338-32,495,283 (from NCBI)

This gene has 10 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in thyroid (RPKM 6.1), colon (RPKM 6.1) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM5 Products(3)

mRNA	Protein	Name
NM_001130710.2	NP_001124182.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001139499.2	NP_001132971.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.3	NP_036454.1	U6 snRNA-associated Sm-like protein LSm5 isoform a

LSM5 Protein Structure

LSM

0
91 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm5

LSM5 U6 small nuclear RNA and mRNA degradation associated

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07860	LSM5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LSM5	RGD	RGD:1308655
Felis catus	LSM5	VGNC	VGNC:80617
Macaca mulatta	LSM5	VGNC	VGNC:108418
Mus musculus	LSM5	MGD	MGI:1913623
Bos taurus	LSM5	VGNC	VGNC:31057