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LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Also Known as YER146W

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23658

About LSM5

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:32,485,338-32,495,283 (from NCBI)

This gene has 10 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in thyroid (RPKM 6.1), colon (RPKM 6.1) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM5 Products (3)

mRNA	Protein	Name
NM_001130710.2	NP_001124182.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001139499.2	NP_001132971.1	U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.3	NP_036454.1	U6 snRNA-associated Sm-like protein LSm5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12515382	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12515382	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM5 Protein Structure

LSM

0
91 a.a.

Protein Preferred Names	Protein Names
U6 snRNA-associated Sm-like protein LSm5	LSM5 U6 small nuclear RNA and mRNA degradation associated

LSM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM5	Q9Y4Y9	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	SPMIP10	Homo sapiens	Q6ZNM6	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	SNRPE	Homo sapiens	P62304	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	SNRPE	Homo sapiens	P62304	Y2H	15231747
Intra	LSM5	Q9Y4Y9	SNRPE	Homo sapiens	P62304	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM5	Q9Y4Y9	LSM3	Homo sapiens	P62310	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	LSM3	Homo sapiens	P62310	Anti Tag CoIP	33961781
Intra	LSM5	Q9Y4Y9	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	25416956
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H Array	31515488
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Validated Y2H	25416956
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Y2H Array	25416956
Intra	LSM5	Q9Y4Y9	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	33961781
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Y2H	15231747
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	SNRPF	Homo sapiens	P62306	Validated Y2H	25416956
Intra	LSM5	Q9Y4Y9	LSM6	Homo sapiens	P62312	Y2H Array	25416956
Intra	LSM5	Q9Y4Y9	LSM6	Homo sapiens	P62312	Y2H	15231747
Intra	LSM5	Q9Y4Y9	LSM6	Homo sapiens	P62312	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	TBPL1	Homo sapiens	P62380	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	TBPL1	Homo sapiens	P62380	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	TCL1B	Homo sapiens	O95988	Y2H Array	32296183
Intra	LSM5	Q9Y4Y9	TCL1B	Homo sapiens	O95988	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	LSM5	Q9Y4Y9	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07860	LSM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LSM5	RGD	RGD:1308655
Felis catus	LSM5	VGNC	VGNC:80617
Macaca mulatta	LSM5	VGNC	VGNC:108418
Mus musculus	LSM5	MGD	MGI:1913623
Bos taurus	LSM5	VGNC	VGNC:31057
Others	LSM5	NCBI