LSM8 - LSM8 homolog, U6 small nuclear RNA associated Gene

Also Known as NAA38

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51691

About LSM8

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:118,184,164-118,204,035 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues.

Summary

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]

LSM8 Products (1)

mRNA	Protein	Name
NM_016200.5	NP_057284.1	LSM8 homolog, U6 small nuclear RNA associated

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM8 Protein Structure

LSM

0
96 a.a.

Protein Preferred Names	Protein Names
LSM8 homolog, U6 small nuclear RNA associated	LSM8 U6 small nuclear RNA associated

LSM8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM8	O95777	LSM2	Homo sapiens	Q9Y333	Y2H	15231747
Intra	LSM8	O95777	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM8	O95777	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM8	O95777	LSM4	Homo sapiens	Q9Y4Z0	Y2H	15231747
Intra	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	LSM8	O95777	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	LSM8	O95777	LSM6	Homo sapiens	P62312	Y2H	15231747
Intra	LSM8	O95777	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	LSM8	O95777	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	LSM8	O95777	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	LSM8	O95777	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	LSM8	O95777	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	LSM8	O95777	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	LSM8	O95777	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	LSM8	O95777	SOD1	Homo sapiens	P00441	Validated Y2H	32814053
Intra	LSM8	O95777	SOD1	Homo sapiens	P00441	Y2H Pooling	32814053
Intra	LSM8	O95777	SOD1	Homo sapiens	P00441	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

LSM8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810118	LSm8 Antibody (YA9462)	WB, IP	human

Related Diseases

Diseases	Alias
Night Blindness, Congenital Stationary, Autosomal Dominant 1	Congenital Stationary Night Blindness Autosomal Dominant 1 CSNBAD1 Rhodopsin-Related Congenital Stationary Night Blindness Night Blindness, Congenital Stationary, Rhodopsin-Related Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 1
Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio Type PN Clericuzio Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia, Clericuzio-Type Clericuzio-Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia Clericuzio Type Immune-Deficient Poikiloderma Clericuzio-Type Poikiloderma Neutropenia Syndrome Poikiloderma With Neutropenia Clericuzio-Type Poikiloderma, With Neutropenia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07863	LSM8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LSM8	VGNC	VGNC:80618
Macaca mulatta	LSM8	VGNC	VGNC:81636
Bos taurus	LSM8	VGNC	VGNC:31060
Mus musculus	LSM8	MGD	MGI:1923772
Canis familiaris	LSM8	VGNC	VGNC:49756
Rattus norvegicus	LSM8	RGD	RGD:1308442
Others	LSM8	NCBI