1. Gene
  2. STRAP - serine/threonine kinase receptor associated protein Gene

STRAP - serine/threonine kinase receptor associated protein Gene

Homo sapiens

Also known as MAWD; PT-WD; UNRIP

Gene ID: 11171 | Gene type: protein coding

About STRAP

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,882,387-15,903,478 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in brain (RPKM 51.3), thyroid (RPKM 49.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]

STRAP Products(1)

mRNA Protein Name
NM_007178.4 NP_009109.3 serine-threonine kinase receptor-associated protein

STRAP Protein Structure

WD40

WD40: WD domain, G-beta repeat (9 - 39)

WD40

WD40: WD domain, G-beta repeat (53 - 87)

WD40

WD40: WD domain, G-beta repeat (98 - 128)

WD40

WD40: WD domain, G-beta repeat (138 - 170)

WD40

WD40: WD domain, G-beta repeat (256 - 292)

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Protein Preferred Names Protein Names

serine-threonine kinase receptor-associated protein

MAP activator with WD repeats

Related Diseases

Diseases Alias
Spastic Paraplegia 8, Autosomal Dominant

SPG8

Hereditary Spastic Paraplegia 8

Autosomal Dominant Spastic Paraplegia Type 8

Autosomal Dominant Spastic Paraplegia 8

Paraplegia, Spastic, Autosomal Dominant, Type 8

Childhood Spinal Muscular Atrophy

Spinal Muscular Atrophies Of Childhood

Survival Motor Neuron Spinal Muscular Atrophy

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1

Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus STRAP MGD MGI:1329037
Macaca mulatta STRAP VGNC VGNC:100110
Rattus norvegicus STRAP RGD RGD:1311114
Bos taurus STRAP VGNC VGNC:35420
Canis familiaris STRAP VGNC VGNC:46941
Others STRAP NCBI