STRAP - serine/threonine kinase receptor associated protein Gene

Also Known as MAWD; PT-WD; UNRIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11171

About STRAP

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,882,387-15,903,478 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in brain (RPKM 51.3), thyroid (RPKM 49.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]

STRAP Products (1)

mRNA Protein Name
NM_007178.4 NP_009109.3 serine-threonine kinase receptor-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15848170 GOA
Biological Process GO Annotation Evidence References Source
involved in maintenance of gastrointestinal epithelium IMP
IMP: Inferred from mutant phenotype
17929853 GOA
acts upstream of positive effect negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23687415 GOA
involved in spliceosomal snRNP assembly EXP
EXP: Inferred from Experiment
12067652 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
18984161 GOA
Cellular Component GO Annotation Evidence References Source
part of SMN complex IDA
IDA: Inferred from direct assay
17178713 GOA
part of SMN complex IPI
IPI: Inferred from physical interaction
17178713 GOA
part of SMN-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17929853 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRAP Protein Structure

WD40

WD40: WD domain, G-beta repeat (9 - 39)

WD40

WD40: WD domain, G-beta repeat (53 - 87)

WD40

WD40: WD domain, G-beta repeat (98 - 128)

WD40

WD40: WD domain, G-beta repeat (138 - 170)

WD40

WD40: WD domain, G-beta repeat (256 - 292)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

serine-threonine kinase receptor-associated protein

  • MAP activator with WD repeats

STRAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
26496610
Intra
STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Pull Down
15848170
Intra
STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
33961781
Intra
STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
28514442
Intra
STRAP Q9Y3F4 NME1 Homo sapiens P15531
Confocal
17314099
Intra
STRAP Q9Y3F4 NME1 Homo sapiens P15531
Y2H
17314099
Intra
STRAP Q9Y3F4 NME1 Homo sapiens P15531
Anti Bait CoIP
17314099
Intra
STRAP Q9Y3F4 NME1 Homo sapiens P15531
Comig Non-Denat Gel
17314099
Intra
STRAP Q9Y3F4 GEMIN6 Homo sapiens Q8WXD5
Anti Tag CoIP
26496610
Intra
STRAP Q9Y3F4 GEMIN6 Homo sapiens Q8WXD5
Pull Down
15848170
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 8, Autosomal Dominant

  • SPG8

  • Hereditary Spastic Paraplegia 8

  • Autosomal Dominant Spastic Paraplegia Type 8

  • Autosomal Dominant Spastic Paraplegia 8

  • Paraplegia, Spastic, Autosomal Dominant, Type 8
Childhood Spinal Muscular Atrophy

  • Spinal Muscular Atrophies Of Childhood

  • Survival Motor Neuron Spinal Muscular Atrophy
Large Cell Carcinoma

  • Carcinoma, Large Cell

  • Carcinoma Large Cell
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Spinal Muscular Atrophy, Type I

  • Werdnig-Hoffmann Disease

  • SMA1

  • Spinal Muscular Atrophy 1

  • Sma I

  • Sma, Infantile Acute Form

  • Muscular Atrophy, Infantile

  • Spinal Muscular Atrophy-1

  • Hmn Proximal Type I

  • Infantile Muscular Atrophy

  • Proximal Spinal Muscular Atrophy Type 1

  • Sma Type 1

  • Sma Type I

  • Sma-I

  • Hereditary Motor Neuropathy Proximal Type I

  • Progressive Muscular Atrophy Of Infancy

  • Proximal Spinal Muscular Atrophy, Type 1

  • Werdnig Hoffmann Disease

  • Infantile Spinal Muscular Atrophy

  • Infantile-Onset Spinal Muscular Atrophy

  • Proximal Hereditary Motor Neuropathy Type I

  • Sma Infantile Acute Form

  • Spinal Muscular Atrophy Type I

  • Werdnig-Hoffman Disease

  • Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy

  • Sma

  • 5q Sma

  • Proximal Sma

  • Sma-Associated Sma

  • Spinal Amyotrophies

  • Spinal Amyotrophy

  • Spinal Muscle Degeneration

  • Spinal Muscle Wasting

  • Muscular Atrophy Spinal

  • Atrophy, Muscular, Spinal

  • Hereditary Motor Neuronopathy

  • Progressive Muscular Atrophy

  • Sma - [Spinal Muscular Atrophy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13761 SRFBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13961 STRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15216 TTC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19745 Strap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26242 Strap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STRAP MGD MGI:1329037
Macaca mulatta STRAP VGNC VGNC:100110
Rattus norvegicus STRAP RGD RGD:1311114
Bos taurus STRAP VGNC VGNC:35420
Canis familiaris STRAP VGNC VGNC:46941
Others STRAP NCBI