GEMIN6 - gem nuclear organelle associated protein 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79833

Summary

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
Ubiquitous expression in testis (RPKM 12.8), lymph node (RPKM 7.5) and 25 other tissues.

GEMIN6 Products (1)

mRNA Protein Name
NM_024775.10 NP_079051.9 gem-associated protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11748230 GOA
Biological Process GO Annotation Evidence References Source
involved in spliceosomal snRNP assembly EXP
EXP: Inferred from Experiment
12067652 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
18984161 GOA
Cellular Component GO Annotation Evidence References Source
located in Gemini of coiled bodies IDA
IDA: Inferred from direct assay
20513430 GOA
part of SMN complex IDA
IDA: Inferred from direct assay
17178713 GOA
part of SMN complex IPI
IPI: Inferred from physical interaction
17178713 GOA
part of SMN-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11748230 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
located in nuclear body IDA
IDA: Inferred from direct assay
11748230 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11748230 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GEMIN6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GEMIN6 Q8WXD5 ACOT11 Homo sapiens Q8WXI4-2
Y2H Array
32296183
Intra
GEMIN6 Q8WXD5 ACOT11 Homo sapiens Q8WXI4-2
Validated Y2H
32296183
Intra
GEMIN6 Q8WXD5 ACOT11 Homo sapiens Q8WXI4-2
Y2H Prey Pooling
32296183
Intra
GEMIN6 Q8WXD5 SNRPD2 Homo sapiens P62316
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 SNRPE Homo sapiens P62304
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 SNRPF Homo sapiens P62306
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 SNRPD1 Homo sapiens P62314
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 SNRPG Homo sapiens P62308
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Y2H Array
31515488
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Validated Y2H
32296183
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
X-Ray Diffraction
15939020
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Complementation
32296183
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
33961781
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
GMS
15939020
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Solution Sedimentation
15939020
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Pull Down
15939020
Intra
GEMIN6 Q8WXD5 GEMIN7 Homo sapiens Q9H840
Y2H Prey Pooling
25416956
Intra
GEMIN6 Q8WXD5 STRAP Homo sapiens Q9Y3F4
Anti Tag CoIP
33961781
Intra
GEMIN6 Q8WXD5 STRAP Homo sapiens Q9Y3F4
Anti Tag CoIP
28514442
Intra
GEMIN6 Q8WXD5 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
GEMIN6 Q8WXD5 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
GEMIN6 Q8WXD5 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
GEMIN6 Q8WXD5 RASL11B Homo sapiens Q9BPW5
Y2H Prey Pooling
32296183
Intra
GEMIN6 Q8WXD5 RASL11B Homo sapiens Q9BPW5
Validated Y2H
32296183
Intra
GEMIN6 Q8WXD5 RASL11B Homo sapiens Q9BPW5
Y2H Array
32296183
Intra
GEMIN6 Q8WXD5 TOX4 Homo sapiens O94842
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction