TOX4 - TOX high mobility group box family member 4 Gene

Also Known as LCP1; MIG7; C14orf92; KIAA0737

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9878

About TOX4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,477,195-21,499,170 (from NCBI)

This gene has 14 transcripts (splice variants), 278 orthologues and 20 paralogues.

Summary

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Part of PTW/PP1 Phosphatase complex. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

TOX4 Products (2)

mRNA Protein Name
NM_001303523.2 NP_001290452.1 TOX high mobility group box family member 4 isoform 2
NM_014828.4 NP_055643.1 TOX high mobility group box family member 4 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Cellular Component GO Annotation Evidence References Source
part of PTW/PP1 phosphatase complex IDA
IDA: Inferred from direct assay
20516061 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20516061 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX4 Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (200 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
Protein Preferred Names Protein Names

TOX high mobility group box family member 4

  • epidermal Langerhans cell protein LCP1

TOX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TOX4 O94842 MYL7 Homo sapiens Q01449
Y2H Array
25416956
Intra
TOX4 O94842 MYL7 Homo sapiens Q01449
Validated Y2H
25416956
Intra
TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra
TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Y2H Array
25416956
Intra
TOX4 O94842 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
25416956
Intra
TOX4 O94842 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
TOX4 O94842 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
TOX4 O94842 TBX6 Homo sapiens O95947
Validated Y2H
32296183
Intra
TOX4 O94842 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra
TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Y2H Prey Pooling
25416956
Intra
TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Y2H Array
25416956
Intra
TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Validated Y2H
25416956
Intra
TOX4 O94842 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
TOX4 O94842 GEMIN6 Homo sapiens Q8WXD5
Y2H Array
25416956
Intra
TOX4 O94842 GEMIN6 Homo sapiens Q8WXD5
Y2H Prey Pooling
25416956
Intra
TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
TOX4 O94842 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
TOX4 O94842 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Intraductal Papillomatosis

  • Breast Papillomatosis

  • Intraductal Papillomatosis Of The Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14911 TOX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TOX4 VGNC VGNC:99334
Rattus norvegicus TOX4 RGD RGD:708449
Canis familiaris TOX4 VGNC VGNC:55005
Felis catus TOX4 VGNC VGNC:66460
Bos taurus TOX4 VGNC VGNC:36230
Mus musculus TOX4 MGD MGI:1915389
Others TOX4 NCBI