MYL7 - myosin light chain 7 Gene

Also Known as MYL2A; MYLC2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58498

About MYL7

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,138,864-44,141,332 (from NCBI)

This gene has 10 transcripts (splice variants), 186 orthologues and 7 paralogues. Restricted expression toward heart (RPKM 2260.5).

Summary

Predicted to enable calcium ion binding activity. Located in A band. [provided by Alliance of Genome Resources, Apr 2022]

MYL7 Products (1)

mRNA Protein Name
NM_021223.3 NP_067046.1 myosin regulatory light chain 2, atrial isoform

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in A band IDA
IDA: Inferred from direct assay
15621049 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL7 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (38 - 130)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

myosin regulatory light chain 2, atrial isoform

  • MLC-2a

MYL7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYL7 Q01449 PSORS1C2 Homo sapiens Q9UIG4
Validated Y2H
32296183
Intra
MYL7 Q01449 MCCD1 Homo sapiens P59942
Y2H Prey Pooling
32296183
Intra
MYL7 Q01449 MCCD1 Homo sapiens P59942
Y2H Array
32296183
Intra
MYL7 Q01449 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
MYL7 Q01449 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
MYL7 Q01449 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
MYL7 Q01449 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MYL7 Q01449 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MYL7 Q01449 PPM1B Homo sapiens O75688-3
Y2H Prey Pooling
32296183
Intra
MYL7 Q01449 PPM1B Homo sapiens O75688-3
Y2H Array
32296183
Intra
MYL7 Q01449 TOX4 Homo sapiens O94842
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Familial Atrial Fibrillation

  • Atrial Fibrillation, Familial

  • Atfb

  • Atrial Fibrillation Autosomal Dominant

  • Autosomal Dominant Atrial Fibrillation

  • Auricular Fibrillation

  • Atrial Fibrillation

  • Atrial Fibrillation, Familial, 1
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08920 MYL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MYL7 VGNC VGNC:31804
Felis catus MYL7 VGNC VGNC:63679
Mus musculus MYL7 MGD MGI:107495
Rattus norvegicus MYL7 RGD RGD:1308262
Macaca mulatta MYL7 VGNC VGNC:75002
Others MYL7 NCBI