SMAP2 - small ArfGAP2 Gene

Also Known as SMAP1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64744

About SMAP2

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,344,834-40,423,326 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 28 paralogues. Broad expression in lymph node (RPKM 80.3), spleen (RPKM 58.9) and 23 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SMAP2 Products (4)

mRNA Protein Name
NM_001198978.2 NP_001185907.1 stromal membrane-associated protein 2 isoform 3
NM_001198979.2 NP_001185908.1 stromal membrane-associated protein 2 isoform 2
NM_001198980.1 NP_001185909.1 stromal membrane-associated protein 2 isoform 4
NM_022733.3 NP_073570.1 stromal membrane-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMAP2 Protein Structure

ArfGap

ArfGap: Putative GTPase activating protein for Arf (15 - 126)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

stromal membrane-associated protein 2

  • stromal membrane-associated GTPase-activating protein 2

SMAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMAP2 Q8WU79 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
SMAP2 Q8WU79 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 SMAP1 Homo sapiens Q8IYB5-2
Y2H Array
32296183
Intra
SMAP2 Q8WU79 SMAP1 Homo sapiens Q8IYB5-2
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
SMAP2 Q8WU79 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 BHLHE40 Homo sapiens O14503
Y2H Array
32296183
Intra
SMAP2 Q8WU79 BHLHE40 Homo sapiens O14503
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
25416956
Intra
SMAP2 Q8WU79 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
SMAP2 Q8WU79 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
25416956
Intra
SMAP2 Q8WU79 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
SMAP2 Q8WU79 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 DAZAP2 Homo sapiens Q15038
Y2H Array
25416956
Intra
SMAP2 Q8WU79 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
SMAP2 Q8WU79 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
Intra
SMAP2 Q8WU79 DAZAP2 Homo sapiens Q15038
Validated Y2H
25416956
Intra
SMAP2 Q8WU79 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 CRX Homo sapiens O43186
Y2H Array
32296183
Intra
SMAP2 Q8WU79 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
SMAP2 Q8WU79 TENT5B Homo sapiens Q96A09
Y2H Prey Pooling
32296183
Intra
SMAP2 Q8WU79 TENT5B Homo sapiens Q96A09
Y2H Array
32296183
Intra
SMAP2 Q8WU79 DAB1 Homo sapiens O75553
Y2H Prey Pooling
25416956
Intra
SMAP2 Q8WU79 DAB1 Homo sapiens O75553
Y2H Array
25416956
Intra
SMAP2 Q8WU79 FAM168A Homo sapiens Q92567
Y2H Prey Pooling
25416956
Intra
SMAP2 Q8WU79 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Kniest Dysplasia

  • Kniest Syndrome

  • Metatropic Dwarfism, Type Ii

  • Kniest Chondrodystrophy

  • Metatropic Dysplasia Type Ii

  • Swiss Cheese Cartilage Dysplasia

  • KD

  • Ks

  • Metatropic Dwarfism Type Ii

  • Dysplasia, Kniest
Vitreous Syneresis

  • Vitreous Degeneration
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Marshall Syndrome

  • MRSHS

  • Deafness, Myopia, Cataract, Saddle Nose-Marshall Type

  • Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis

  • Pfapa Syndrome

  • Pfapa

  • Marshall Syndrome With Periodic Fever

  • Periodic Fever-Aphtous Stomatitis-Pharyngitis-Adenopathy Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120272 SMAP-2 Activator 99.54% Unkown
HY-RS01609 BRD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13402 SMAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13445 SMOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19238 Smap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25727 Smap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SMAP2 VGNC VGNC:65461
Canis familiaris SMAP2 VGNC VGNC:54223
Mus musculus SMAP2 MGD MGI:1917030
Macaca mulatta SMAP2 VGNC VGNC:77772
Rattus norvegicus SMAP2 RGD RGD:1308418
Bos taurus SMAP2 VGNC VGNC:34984
Others SMAP2 NCBI